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تقييم الظهور النسيجي الكيميائي المناعي لفايروسات (EBV,HPV16 - 18,HSV1) في الحزاز المنبسط الفموي == Assessment of The Immunohistochemical Expression of Epstein - Barr , Human Papilloma (18 ,16) And Herpes Simplex - 1 Viruses In Oral Lichen Planus
Author name:
تانیه عبد الاله الطحان
Supervisor name:
احلام حمید مجید
General topic:
Dentistry
Specific topic:
Around the Teeth Diseases
Degree:
Master
University:
University of Baghdad - Faculty Of Dentistry - Department Of Periodontics And Peridontics
Language:
English
University location:
Baghdad
First pages:
20T378 - p.pdf
Abstract:
يعد مرض الحزاز المسطح الفموي من الامراض الشائعة ولة مسار مرضي مرتبط بالخلايا المناعية ويرتبط باختلالات الاداء المناعي للجسم مع بعض الفرضيات التي تربط وقوع المرض بالعدوى الفايروسية. وھو من عائلة الھربس الفايروسية، بوقوع بعض الامراض ك "كثرة الوحيدات، EBV ار | oral lichen planus (OLP) is a common chronic inflammatory immune - mediated disease, The antigen responsible for inducing OLP is still unidentified, although viral agents have been proposed as etiologic factors. Viral infection (Epestin - barr,human papilloma and herpes simplex) has been hypothesized as a predisposing factor in the pathogenesis of this disease.Aims of study : The aim of this study was to assess the expression of Epstein Barr virus , Human Papilloma virus 16& 18 and Herpes Simplex virus - 1 immunohistochemistry in oral lichen planus cases and evaluate whether any clinical variant, histopathological or demographic feature correlates with the expression of these viruses.Materials and Methods : This study was performed on thirty formalin fixed, paraffin - embedded tissue Blocks of oral lichen planus retrospectively. An immunohistochemical staining done by using monoclonal antibodies EBV and HPV 18&16 and polyclonal antibody HSV1. Results : Expression of EBV was highly detected in epithelium of oral lichen planus cases (46.6%), no statistically significant correlation was found with clinical parameters.Astatistically significant with sex was observed.Immunostaning results revealed negative expression for both HPV16 & HPV18 in the studied cases except one case which was positive for each viruses. No statistically correlation was found with clinical parameters. Herpes simplex virus - 1 expression was positive in 12 cases (40%) of oral lichen planus cases. Statistically barely significant correlation with sex and clinical types, and a non significant one wasfound with age.ConclusionEpstein Barr and Herpes simplex viruses are present in considerable amounts in oral lichen planus whereas Human papilloma viruses 16 and 18 are rarely present.Taking into account the potential of viruses in OLP.
