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دراسة تاثير اللا نسوبرازول وبعض النباتات الطبية على القرحة المعدية المحدثة بواسطة الكحول الاثيلي في الجرذان == A study of the effect of Lansoprazole and some medicinal plants on Ethanol - induced gastric lesion in Rats
Author name:
صابرين سعد العاني
Supervisor name:
فاروق حسن الجواد
General topic:
Medicine
Specific topic:
Medicines and Toxins
Degree:
Master
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1398 - p.pdf
Abstract:
It is well documented that intake of highly concentrated dose of ethanol has injurious effect on gastric mucosa. Many mechanisms have been implicated in the pathogenesis of gastric lesions induced by ethanol. Some drugs and aqueous extract of medicinal plants were used in the current study to explore their effectiveness and whether may be helpful to reduce the injurious effect of ethanol and to produce possible gastric cytoprotective action.The parameters of gastric mucosal lesion were measured before and after administration of Lansoprazole, aqueous extract of Curcuma, Marshmallow, Slippery Elm, Calendula, Chamomile and Garlic , In addition to measurement of the serum glucose, calcium ,potassium and sodium levels and the possibility of having any change in their values after administration of ethanol. The obtained results can be summarized as the following : - • Ethanol was found highly effective to induce gastric lesion in ratio of 100% when administered orally. This effect was associated with significant rise of serum glucose level and decrease of calcium level but with no significant change in serum levels of potassium and sodium.• Lansoprazole is one of proton pump inhibitors (0.04 mg/kg) was given orally 1 hour before ethanol administration produced highly significant reduction in gastric lesion parameters with preventive index equal to 95% and suggestive a possible cytoprotective property of the drug. This effect was accompanied with slight increase in glucose level and insignificant change in serum calcium, potassium, and sodium levels.• Curcuma its aqueous extract has antioxidant effect, 1.5 ml was given orally, produced highly significant reduction in gastric lesion parameters with preventive index equal to 93% and this effect was associated with no significant changes in the serum glucose, calcium, potassium, and sodium levels.III• The aqueous extract of Marshmallow, Slippery Elm, Calendula and Chamomile 1.5 ml was given orally for each, produced significant decrease in gastric lesion parameters with preventive index equal to 42%, 46%, 14.6% and 15.8% respectively. This effect was associated with significant increase in serum glucose level of the first two plants and with significant decrease in glucose level of the later twoplants .There is no significant changes in serum calcium, potassium and sodium levels of these medicinal plants except Chamomile.• The aqueous extract of garlic 1.5 ml was given orally produced significant rise in gastric lesion parameters which completely differ from the effect of other medicinal plants. This effect was accompanied with significant reduction in serum glucose and potassium levels.The obtained results in this study indicated that all medicinal plants except garlic have beneficial cytoprotective action on the gastric mucosa and the possibility of using these plants in clinical trials as gastric cytoprotective remedy for patients with gastric ulcer.
