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دراسة فسلجية لمرضى الفشل الكلوي قبل وبعد الديلزة في محافظة واسط == A Physiological Study of Renal Failure Patients Pre And Post Dialysis In Wasit Province
Author name:
تمارة حمد احمد العقبي
Supervisor name:
كاظم جهيد كاطع الطائي | هيثم قاسم محمد
General topic:
Biology
Specific topic:
Zoology - Physiology
Degree:
Master
University:
Wasit University - College Of Science - Department Of Biology
Language:
English
University location:
Wasit
First pages:
24T2652 - p.pdf
Abstract:
تم اجراء هذه الدراسة في كلية العلوم/ قسم علوم الحياة في جامعة واسط وبالتعاون مع مركز الكلية الصناعية في محافظة واسط للفترة من 1/10/2012 ولغاية 1/5/ 2013 لغرض دراسة التغيرات الفسلجية التي تحدث لمرضى الفشل الكلوي بنوعيه الغسيل الدموي والغسيل البريتوني قبل و| This study was conducted in the Department of Biology, College of Science, University of Wasit. The samples were collected in cooperation with artificial kidney center in AL - Kut Hospital, AL - Kut city, Wasit Province, during the period from 1 /10/2012 to 1/5/2013. In order to study the physiological changes of renal failure patients before and after hemodialysis and peritoneal dialysis. The blood samples were taken from one hundered thirty four patients for this study.The patients in this study were divided into two groups according to the type of dialysis : 94 hemodialysis patients, 52 males with age range (21 - 69) years and 42 females with age range (20 - 70) years, 40 peritonial dialysis patients, 24 males with age range (21 - 60) years and 16 females with age range (23 - 63) years. All results were compared with the results of 57 healthy person who were selected from both sexes (29 males and 28 female). Eight milliliters of venous blood were collected from control subjects and patients with renal failure by using disposable syringe of 10 ml before and after dialysis process.The blood analyses was conducted for evaluating the hematological parameters which are included (Hb, PCV, WBCs and PLT ) biochemical parameters which include (Blood Urea, Serum Creatinine, Total Protein and Calicum) electrolyte parameters which include sodium and potassium, measured concentration of (Erythropoietin and Aldosterone) hormone in patients with renal failure before and after dialysis and control groups and measure the effectiveness of phagocytic cells in patients with renal failure before dialysis by using Nitroblue Tetrazolium stain (NBT). The study revealed the following results : 1 - When comparing the results of parameters between before and after hemodialysis and peritoneal dialysis with healthy control show the following : a - Significant decrease (P < 0.01) in the levels of (Hb and PCV) while significant increase (P < 0.01) in PLT in renal failure patients before and after dialysis compared to healthy control and significant increase (P < 0.01) in the numbers of WBCs in male peritoneal dialysis patients compared to healthy control.b - Significant increase (P < 0.01) in urea, creatinine, sodium, potassium and in the aldosterone hormone concentration in renal failure patients before and after dialysis compared to healthy control.c - Significant decrease (P < 0.01) in the erythropoietin hormone concentration, total protein, calcium and phagocytic cells activity in renal failure patients compared to healthy control.2 - When comparing the results of parameters between before and after dialysis for each type of dialysis showing the following : - a - All hematological parameters and the concentration of hormones (Erythropoietin and Aldosterone) observe no significant differences between before and after dialysis.b - Significant decrease in the levels of urea, creatinine and there is a significant increase in the levels of total protein and calcium after dialysis comparing with before dialysis.c - Significant decrease in the levels of potassium in hemodialysis patients after dialysis comparing to before dialysis and there is a significant decrease in the levels of sodium and potassium after peritoneal dialysis comparing to before dialysis. 3 - When comparing the results of males and females hemodialysis with males and females peritoneal dialysis shows the following : a - Significant increases in numbers of WBCs before and after dialysis in the male and female peritoneal dialysis comparing with hemodialysis b - Significant decreases in the levels of urea and creatinine after dialysis in the male and female peritoneal dialysis comparing with hemodialysis.c - No significant difference in the levels of Hb, PCV, PLT, total protein, calcium, sodium, potassium, the phagocytic activity and the concentration of hormones (Erythropoietin and Aldosterone) before and after dialysis in the male and female hemodialysis comparing with peritoneal dialysis. We conclude that renal failure patients in Wasit Province suffer from severe anemia, high blood pressure, increase in the levels of urea and creatinine, disturbance in the levels of potassium, sodium and calcium with deficiency in the body's immunity.
