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العلاقه بين الهموسستين,البروتين الرابط للرتينول,البري البومين,والالبومين في الحمل العنقودي الجزئي
Author name:
قاسم عبد عزيز عيدان
Supervisor name:
حيدر هاشم الشلاه | نادية مضر الحلي
General topic:
Medicine
Specific topic:
Clinical Biochemistry
Degree:
Master
University:
University of Babylon - Faculty Of Medicine
Language:
English
University location:
Babylon
First pages:
19T1712 - p.pdf
Abstract:
Hydatidiform mole is a premalignant condition, refers to an abnormal pregnancy characterized by varying degrees of abnormal trophoblastic proliferation. Several potential etiologic risk factors have been evaluated for the development of Hydatidiform Mole. These include the extreme of maternal age, prior Hydatidiform Mole, deficiency of Beta - carotene and animal fat intake.The aims of this study were to assess nutritional status as a possible cause of partial Hydatidiform mole and to investigate the changes in these markers in the first trimester pregnant women compared to non - pregnant.This study was conducted in Babylon Maternity and Pediatrics Teaching Hospital in Babylon Province and Al Zahraa teaching hospital in Al Najaf Province from the first of September 2016 to the end of March 2017.This study included 75 subjects, 25 were patients diagnosed with partial hydatidiform mole, the other 25 pregnant women in the first trimester were healthy subject (first control group), and the remainder 25 non pregnant women were healthy subject (second control group). Patients who suffered from metabolic or endocrine disease, renal dysfunction, and BMI > 30 were excluded.The sera obtained from the fasting blood of subjects were used to measure the level of homocysteine, Retinol binding protein, pre albumin, and albumin).The results of the present study showed that the mean age of patients group was (27.44 ± 5.36) years, ranging from 18 - 39 years and the peak incidence of partial hydatidiform mole between 22 - 29 years. The majority (76%) of patient with partial hydatidiform mole came from rural area. Accident finding at ultrasonography was the commonest way of presentation (44%) followed by vaginal bleeding (40%) while (16%)XIhyperemesis gravidram. the mean level of retinol binding protein was non significantly higher in the control group (366.4 ± 118.2 ng/ml vs. 326.5 ± 109.4 ng/ml; P=0.222). The Prealbumin levels were significantly lower in the pregnant patient women with partial hydatidiform mole compared with healthy pregnant women control group (18.71 ± 5.08 mg/dl vs. 23.40 ± 2.39 mg/dl; P < 0.001). There were no significant differences between blood levels of homocysteine and albumin in patient's women compared to healthy pregnant women (7.3 ± 2.0 mmol/l vs. 6.5 ± 1.92 mmol/l, P = 0.146), (3.98 ± 0.56 g/dl vs. 4.10 ± 0.25 g/dl, P = 0.337) respectively. The mean plasma homocysteine levels between first trimester pregnant women and non - pregnant was statistically lower (6.5 ± 1.92 mmol/l vs 10.02 ± 2.48 mmol/l; P < 0.001) respectively. The mean of serum albumin levels between first trimester pregnant women and non - pregnant was found statistically significant difference (4.10 ± 0.25 g/dl vs 4.58 ± 0.44 g/dl; P < 0.001) respectively. In conclusion, the highest percentage of patients with Partial Hydatidiform Mole belonging to the rural area, in nulliparous and low parous patients having 1 - 2 children. This study suggests that there was an association between prealbumin and Partial Hydatidiform Mole. There was no association between homocysteine and Partial Hydatidiform Mole.
