Share
جفاف الفم الحاد الناتج من العلاج الاشعاعي للراس والرقبة == ACUTE XEROSTOMIA IN HEAD AND NECK RADIOTHERAPY
Author name:
داليا سعد عبود عبد الله
Supervisor name:
خضير جاسم صبيح الرواق
General topic:
Medicine
Specific topic:
Therapeutic Radiology
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1454 - p.pdf
Abstract:
Background : Xerostomia, the subjective experience of dry mouth, is among the most common complaints experienced by cancer patients treated with radiotherapy to the head and neck area. It is caused by salivary gland dysfunction as a result of damage in the field of radiation.Aim of this study : To identify the incidence and determinants of xerostomia and its grades in a section of HNC patients receiving radiotherapy in IraqMethods : A prospective observational study conducted in the Oncology Teaching Center/ Radiation Therapy Department at the Medical City Complex, Baghdad, Iraq during a period of six months from (Nov. 2017 to Apr. 2018). It involved 100 patients diagnosed with HNC and received radiotherapy. The data collection was done through daily visits and study patients were selected randomly. The dose of External Beam Radiotherapy used for the treatment of different patients was (30 Gray - 70 Gray), with a standard fractionation. The patients were assessed for symptoms and signs of xerostomia according to subjective experience of dry mouth and patients were classified by xerostomia grades into mild, moderate, and severe.Results : Total no. of patients was 100 and the mean age was 51.69 ± 13.7 years; 67% were males and 33% were females. Most of them were non - drinker and had no past medical history (91% and 80% respectively); 54% were former smokers. Nasopharyngeal tumor and larynx cancer were the commonest tumors diagnosed (29% and 28% respectively), 78% of the tumors were squamous cell carcinoma type and 53% of them were in stage III. Most of the study patients didn’t take chemotherapy during radiotherapy (90%), while 68% of them have previously received chemotherapy. The mean dose of radiotherapy used was 63.2 ± 9.65 GY. Post radiotherapy, the highest proportion of study patients were diagnosed with xerostomia grade I (37%), while 21%IIof them were free of xerostomia. Female gender, negative past medical history, site of tumor, stage of tumor and dose of radiation were significantly associated factors (P < 0.05) that increased prevalence of xerostomia. While tumor site was significant factor associated with grade of xerostomia.Conclusion : After radiotherapy, there is a high chance for developing xerostomia. Females, negative past medical history, advanced stage of tumor, high dose of radiation and site of tumor (oral, nasopharyngeal, and parotid) were significantly associated factors. Tumor site was a significant factor associated with the grade of xerostomia.
