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التقييم التجريبي لتاثير الروزفستاتين المضاد للالم والمضاد للالتهاب وتداخله مع السليكوكسب والباراسيتامول == Experimental Evaluation of The Antinociceptive And Anti - Inflammatory Effects of Rosuvastatin And Its Interaction With Celecoxib And Paracetamol
Author name:
سرمد عبد العباس كشمر
Supervisor name:
عبد الله محمد جواد
General topic:
Medicine
Specific topic:
Medicines and Toxins
Degree:
Master
University:
University Of Basrah - Faculty Of Medicine - Department Of Medicine
Language:
English
University location:
Basrah
First pages:
19T1101 - p.pdf
Abstract:
اظهرت الدراسات بان الستاتينات تؤدي الى تقليل الوفيات بدرجة اكبر من ان تعزى الى تاثيرها الخافض للكوليستيرول بمفرده لان الفائدة حدثت بشكل اسرع مما يمكن تفسيره على وفق الالية سالفة الذكر. هذه الفوائد يمكن ان يكون لها علاقة بتاثيرات الستاتينات المضادة للالتها | Studies revealed that statins can result in a larger mortality benefits than can be readily explained by their cholesterol - lowering effect alone since they occur too quickly to be explained by the above cited mechanism. These benefits might be related to the anti - inflammatory and other effects statins may have.AimTo find out the extent to which rosuvastatin (a hydrophilic statin) can be considered as an antinociceptive and anti - inflammatory drug in comparison to two standard drugs; paracetamol and celecoxib, and whether its potential antinociceptive effect differs in different pain models. The interaction of rosuvastatin with paracetamol and celecoxib will also be investigated. MethodsMice (a total of 132) of either sex, 3 - 4 weeks of age, 20 - 25 gm body weight, were used (22 mice for each of six groups). Tests for nociception : tail flick, hot plate and formalin tests; and for inflammation (formalin for chronic inflammation, carrageenan - induced paw edema, and TNF - alpha level in blood) were used. Rosuvastatin (7mg/kg), paracetamol (40mg/kg), celecoxib (6mg/kg) or their combination were administered orally once daily in a volume of 0.2 ml. TNF alpha level in blood was measured using ELISA kit.ResultsThe antinociceptive effect of rosuvastatin when investigated in mice using tail flick, hot plate and formalin tests, showed that rosuvastatin has a mild antinociceptive effect which is much less than that of paracetamol and celecoxib tested in the same pain models. It increased the latency for tail flick by only 13.3% when compared to pre - treatment measurements, and in formalin test, it reduced the licking time by 20.9% in comparison to control. The administration of rosuvastatin with either paracetamol or celecoxib did not add to the antinociceptive effects of the latter two drugs (except in formalin test of pain model). None of the above mentioned drugs significantly reduced hind - paw edema when measured 24 hours after formalin injection, while they produced a significant edema - reducing effect after 14 days. Rosuvastatin and paracetamol had nearly similar effect (54.12% and 58.37% reduction compared with control). Celecoxib reduced the hind - paw edema by 73%. Again there was no additive effect between rosuvastatin and either paracetamol or celecoxib; in contrast, rosuvastatin reduced nearly all the effects of celecoxib when given in combination. Similar trend was found when edema was induced by carrageenan injection. TNF alpha level in blood had been reduced by all the three drugs and their combinations but did not reach statistical significance except in the group of rosuvastatin and paracetamol combination.ConclusionRosuvastatin showed a significant antinociceptive effect in tail flick and in formalin test, but not in hot plate test. It had anti - inflammatory and edema - reducing effects in models of inflammation in mice but the effect was less than that of celecoxib and even paracetamol. These rosuvastatin effects did not add to those of paracetamol and had caused a reduction in celecoxib (except for formalin pain model) effects when given in combination.
