Share
العلاقة بين مختلف مؤشرات فعالية المرض والحالة الوظيفية في عينة من المرضى العراقيين المصابين بالتهاب الفقار المقسط == Correlation Among Different Disease Activity Parameters and Functional Status in a Sample of Iraqi Patients with Axial Spondyloarthritis
Author name:
اروى حمدان خضير
Supervisor name:
نزار عبد اللطيف جاسم
General topic:
Medicine
Specific topic:
Diseases - Joints
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1435 - p.pdf
Abstract:
Background : Axial spondyloarthritis is an inflammatory rheumatic diseasethat comprises the whole spectrum of patients with radiographic sacroiliitis(ankylosing spondylitis or radiographic axial spondyloarthritis) and withoutradiographic sacroiliitis (non - radiographic axial spondyloarthritis). It ischaracterized predominantly by inflammatory back pain and involvement ofthe spine and sacroiliac joints. Disease activity scores like Bath AnkylosingSpondylitis Disease Activity Index and Ankylosing Spondylitis DiseaseActivity Score are used for monitoring the disease activity, while BathAnkylosing Spondylitis Functional Index is used to evaluate the functionalstate of the patients.Aim of the study : to assess the correlation among disease activity scoresand the functional status of patients with axial spondyloarthritis andevaluating the discriminative power of Ankylosing Spondylitis DiseaseActivity Score (ability to reflect disease activity).Patients and methods : A cross sectional study enrolled a total of 251patients with axial spondyloarthritis , all of them were fulfilling the modifiedNew York criteria for Ankylosing Spondylitis and Assessment ofSpondyloarthritis International Society classification criteria for diagnosingspondyloarthropathy. Demographic data, disease duration, type of treatment,Bath Ankylosing Spondylitis Disease Activity Index, AnkylosingSpondylitis Disease Activity Score and Bath Ankylosing SpondylitisFunctional Index were calculated for the patients. They were alsoinvestigated for C - reactive protein and erythrocyte sedimentation rate.VIIResults : The mean age of the patients was (37.2 ± 8)years, males constitute 90.4% of them and the median disease duration was 7 (0.25_42) years. The disease activity scores were positively correlated with each other and with Bath Ankylosing Spondylitis Functional Index with significant p values(<0.005). There was no significant difference between areas under the curve for both Bath Ankylosing Spondylitis Disease Activity Index & Ankylosing Spondylitis Disease Activity Score - Erythrocyte sedimentation rate(0.94 and 0.93 respectively) in comparison to Ankylosing Spondylitis Disease Activity Score - C - reactive protein with area under the curve 0.57, when using patient global assessment as a reference guide to evaluate the ability of the these scores to reflect disease activity.Conclusions : There was a positive correlation among disease activity scores and functional status measured by Bath Ankylosing Spondylitis Functional Index. Ankylosing Spondylitis Disease Activity Score - Erythrocyte sedimentation rate was as good as Bath Ankylosing Spondylitis Disease Activity Index in discrimination of disease activity, while Ankylosing Spondylitis Disease Activity Score - C - reactive protein showed less accuracy in reflecting disease activity.
