Share
انتشار اضطراب الكئابه العظمى لدى المرضى العراقيين المصابين بالتصلب المجموعي == Prevalence of Major Depressive Disorder in Iraqi Patients with Systemic Sclerosis
Author name:
رؤى ناجي سوادي
Supervisor name:
فائق ايشو كوريال | مشتاق طاب هاشم
General topic:
Medicine
Specific topic:
Diseases - Joints
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1423 - p.pdf
Abstract:
Background : Systemic sclerosis (SSc) is a connective - tissue disease characterized by excessive collagen deposition in the dermis and internal organs, and by vascular hyper - reactivity and obliterative microvascular phenomena. Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings, and sense of well - being.Objectives : The aim of this study was to evaluate the prevalence and predictors of major depressive disorder in Iraqi patients with SSc if present.Patients and methods : This case - control study involved 50 patients with SSc according to the criteria developed by the 2013 American College of Rheumatology/European League Against Rheumatism for the classification of systemic sclerosis ,and compared with another 51 healthy controls.Demographics and clinical data were collected including age, sex, BMI, smoking status, marital status, employment status, educational status, crowding index and disease duration. Disease activity for SSc was assessed with the SAQ. Medications used and autoantibody profile were collected.We applied DSM5 diagnostic criteria of all patients included .Results : The prevalence of major depressive disorder was (44% compared to control 2.0%), in which major depressive disorder 39.3 folds associated with SSc patients compared to control. A severe form of major depressive disorder was observed in (36.4 %) of SSc cases. Furthermore, cases with a severe form of disease evaluated by SAQ had an obviously higher rate of depression .Also the risk of having major depressive disorder was significantly correlated with smoking.Educational level had no statistically significant association with major depressive disorder, SSc cases with higher education(college) had the highest rate of major depressive disorder (36.4%) compared to a rate between 13.6% and 27.3% for lower level of educational attainment. The risk of having major depressive disorder was not different in the age, gender, marital status and employment status. The history of using each of prednisolone, DMARD and biological agents had statistically significant association with major depressive disorder. Also the presence of autoantibodies (anti centromer and anti Scl70 antibodies) had no statistically significant effect on the presence of major depressive disorder.Conclusions : The prevalence of major depressive disorder in systemic sclerosis patients was significantly higher in patients compared to controls.Severity of systemic sclerosis was increase the rate of major depressive disorder .
