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تاثير عقار البريدنيزولون في بعض مناسيب الدم الهرمونية والكيموحيوية لدى مرضى الربو القصبي من الرجال في محافظة النجف الاشرف == Effect of Prednisolone Medicine On Some Hormonal And Biochemical Levels In Bronchial Asthma Patients of Men In Al - Najaf Governorate
Author name:
نور زهير جاسم
Supervisor name:
ارشد نوري غني الدجيلي
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
University of Kufa - College Of Science - Department Of Biology
Language:
Arabic
University location:
Najaf
First pages:
24T2819 - p.pdf
Abstract:
هدفت الدراسة الحالية لمعرفة تاثير عقار البريدنيزولون في بعض المناسيب الهرمونية والكيموحيوية لدى مرضى الربو القصبي من الرجال, اذ اجريت هذه الدراسة في مستشفى الصدر التعليمي في محافظة النجف الاشرف \ مركز الحساسية والربو للمدة من 1\7\2011 الى 1\1\2012. تم فحص | The present study was concerned to investigate the effect of prednisolone medicine in some of hormonal and biochemical levels in patients with bronchial asthma of men. The study was carried out in Sadr Teaching Hospital in Najaf City \ Center of Allergy and Asthma for the period from 1 \ 7 \ 2011 and up to 1 \ 1 \ 2012, (56) blood samples from men with bronchial asthma and who treated by prednisolone were tested. As well as a Healthy group consisting of (24) healthy persons who do not suffer from any health problems, the effect of medicine was tested on study levels. The statistical analysis of the results revealed that there was a significant increase (P<0.05) in the concentration of Triiodothyronine Hormone (T?) in patients with bronchial asthma of men who treated by prednisolone compared with Healthy group. The statistical results also showed a significant decrease (P<0.05) in the concentration levels of Thyroid Stimulating Hormone (TSH), Follicle - Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Testosterone Hormone in asthmatic group compared with Healthy group. The results of the biochemical investigations revealed a significant increase (P<0.05) in the concentration of Total Cholesterol, Triglycerides, Low Density Lipoprotein (LDL) and liver enzymes Alkaline Phosphatase ALP, Alanine & Aspartate Transaminase (ALT, AST), and lack of significant difference in the concentration of High - Density Lipoproteins (HDL) in the asthmatic group compared with Healthy group. The results of the current study also exhibited a significant increase (P<0.05) in the concentration of T? for the age group (21 - 30) years of the patient group, whereas the same asthmatic group recorded a significant decrease (P<0.05) in the concentration of FSH, LH and Testosterone Hormone in compared with Healthy group. The results of the study revealed a significant increase (P<.05) in the concentration of Total Cholesterol, Triglycerides, LDL and alkaline phosphatase ALP for the age group (41 - 50) years in asthmatic patients compared with Healthy group. The results of the current study also showed that the concentration of the TSH, FSH, LH and Testosterone Hormone had declined significantly (P<0.05) in asthmatic group who treated by prednisolone for (16 - 20) years compared with Healthy group. The concentration of Total Cholesterol, Triglycerides and liver enzymes Alkaline Phosphatase, Alanine Transaminase and Aspartate Transaminase (ALP, ALT and AST) had risen significantly (P<0.05) in asthmatic group who treated by the prednisolone for (16 - 20) years compared with Healthy group. The current study concluded that Treatment with prednisolone has hormonal and biochemical effects on bronchial asthmatic patients in all ages
