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دور بعض العناصر النزرة في مرض التشنج الحمي البسيط عند الاطفال == The Role of Some Trace Elements in Simple Febrile Convulsion
Author name:
ازاد فرحان هواس اسد
Supervisor name:
حيدر هاشم الشلاه | عدنان حنظل الجوذري
General topic:
Medicine
Specific topic:
Clinical Biochemistry
Degree:
Master
University:
University of Babylon - Faculty Of Medicine
Language:
English
University location:
Babylon
First pages:
19T1717 - p.pdf
Abstract:
Febrile convulsion is one of the most common seizure disturbances in children with an approximate rate of 2 to 5 percent. Febrile seizures are seizures that occur between the age of 6 months and 60 months with a temperature of 38°C or higher, that are not the result of central nervous system infection or any metabolic imbalance, and that occur in the absence of a history of prior a febrile seizures. This study was carried out in Babylon Teaching Hospital for Gynecology and Pediatrics, Hilla City, Babylon Province. The samples of the patients are collected from the outpatient clinic and emergency room, during the period between August 2016 till February 2017.The sample population included 150 children, fifty of them were patients, 25 males (50%) and 25 females (50%) diagnosed with simple febrile convulsion and the other one hundred ,fifty with only fever, 30 males (60%) and 20 females (40%) and finally fifty of healthy subjects, 28 males (56%) and 22 females (44%).The parameter included in this study were (copper, zinc, selenium, magnesium, free ionized calcium, sodium and potassium) and comparative study between two techniques (atomic absorption spectrophotometry and manual spectrophotometer) in determination of trace elements.In the present study, the results showed significant increase in copper level in patient group in comparison with fever without convulsion group and healthy group p.value (< 0.05).Furthermore, it showed a significant low level of zinc and magnesium, in patients with febrile convulsion in comparison with other groups (only fever without convulsion and healthy person), p.value (<0.05).IIThe present study showed significant differences, in the means of potassium and sodium in group of patients with febrile convulsion and only fever without convulsion. Also there were significant differences between means of potassium and sodium in group of patients with febrile convulsion and healthy group, p.value (<0.05).There were no significant differences in means of the results of free ionized calcium and selenium in group of patients with febrile convulsion with other groups.Also the trace elements rather than selenium in the present study were done by two methods, atomic absorption spectrometry techniques, and spectrophotometric method. It was found differences between the two methods and the results obtained by these two methods were highly variant, according to validity test and ROC curve (receiver operating characteristic curve), which done to compare between atomic absorption technique and colorimetric method and the results obtained from atomic absorption showed highly (sensitivity, specificity and accuracy) in compared with the results of colorimetric method. the study concluded that changes in zinc, copper and magnesium levels could play a role in the development of simple febrile convulsion, also depending on the results obtained, the atomic absorption technique is considered superior for trace elements determination.
