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الاضطرابات الفسلجية والاجهاد التاكسدي لدى النساء في سن بعد الياس في محافظة بابل == Physiological Disturbances And Oxidative Stress In Postmenopausal Women In Babylon Province
Author name:
سارة حاتم عجيل خضير
Supervisor name:
داخل غاني عمران الوطيفي
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
University of Babylon - College Of Science For Girls - Department Of Biology
Language:
Arabic
University location:
Babylon
First pages:
24T2814 - p.pdf
Abstract:
يتميز سن الياس (Menopause) لدى الاناث بتوقف الحيض وتصبح الانثى غير خصبة بسبب فقدان جميع الحويصلات المبيضية (Ovarian follicles) والانخفاض الشديد لهرموني الاستروجين والبروجسترون صممت الدراسة الحالية لفحص الاضطرابات الفسلجية المختلفة والتي تشمل بعض المعايير | Menopause marks the time in women's life when her menstruation stop and she is no longer fertile because of exhaustion of ovarian follicles and sharply decrease in ovarian production of estrogen and progesterone.The present study was designated to determinate different physiological disturbances which occurring in some hematological and biochemical parameters of postmenopausal women. A total number used was 130 women, 100 women were postmenopause and subdivided into four age groups (46 - 50 year, 51 - 55 year, 56 - 60 year, and 61 - 65 year). Thirteen women were premenopause , used as a control group, their ages ranged between 20 - 30 years. In all age groups of postmenopausal women, it have been found that the levels of estradiol hormone were progressioly decreased (p<0.05) when compared with control group. Regarding hematological parameters, RBCs count was insignificantly increase (p>0.05) in all age groups of postmenopausal women. Levels of hemoglobin concentrations and packed cell volume were significantly increased (p<0.05) in all age groups of postmenopausal women compare to control groups. Blood platelets count recorded insignificant fall (p>0.05) in most age groups of postmenopausal women.As for, red blood indices (MCV, MCH, and MCHC) explained insignificant differences (p>0.05) of most menopausal women in a comparison with those control group. Total white blood cells have insignificant elevation (p>0.05) of most groups except 56 - 60 years groups. Regard to differential white blood cells, Levels of lymphocytes and monocyte have been showed insignificant drop (p>0.05) of the level of lymphocytes and significant increase (p<0.05) of first and second age groups in the levels of monocytes of postmenopausal women. Granulocytes white blood cells have been indicated different changes : Nentrophils were significantly higher (p<0.05)in all age groups of postmenopausal women, where as, eosinophils and basophils were insignificantly different (p>0.05) in most age groups. Concerning biochemical changes, Total serum proteins, Albumin, and globulin have been showed significant lowering (p<0.05) in all age groups of postmenopausal women. Statistical analyses showed a significant rise (p<0.05) of serum uric acid and urea levels in most group of postmenopausal women. Measurments of enzyme activities involved in liver (ALT and AST) were significantly hightened (p<0.05) in most age groups of postmenopausal women, Whil, ALP activities recorded insignificant increase (p>0.05) in all age group of postmenopausal women. Determinations of minerals showing a significant increase (p<0.05) in the levels of calcium and insignificant increase (p>0.05) in the levels of phosphorus in all groups of post menopausal women. Analyses of electrolytes have been explained a significant elevation (p<0.05) of the sodium and non significant difference (p>0.05) of the potassium in all groups of postmenopausal women.The present study involved determination specific and essential trace elements, Levels of copper explained a significant decrease (p<0.05) in all age groups associated with a significant increase (p<0.05) of zinc levels in postmenopausal women. Inversly, Values of magnesium were insignificantly different (p>0.05) in all age groups of postmenopausal women. The present study selects specific parameters to explaine oxidative stress in postmenopausal women. Levels of malondeheyds were significantly elevated (p<0.05) in all groups of postmenopausal women, and correlated negatively (r= - 0.102) with level of estrogen. Values of reduced glutathione showed a significant decrease (0.05) in postmenopausal women and correlated positively (r=0.64) with the estrogen hormone. Analyses of antioxidants enzymes have been showed a significant decrease (p<0.05) in the activity of catalase enzymes of all groups of postmenopause. Also, the activity of glutathione peroxidase was significantly decrease (p<0.05) in postmenopausal women and its correlation coefficient was r=0.263. In conclusion, changes summarized above may be attributed to deficiency of estradiol hormone in postmenopausal women which resulting in different physiological disturbances and these changes become aggravated and exacerbated because of oxidative stress occurring in decrease of estradiol hormones.
