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مقارنة المقاطع السهمية لسلسلتي الرنين المغناطيسي : استرداد الانقلاب قصير T1 وT2 الموزونة ذوات صدى الانفتال السريع في الكشف عن افات الحبل الشوكي الناجمة عن تصلب الاعصاب المتعدد == A Comparison of Sagittal Sections of Short T1inversion Recovery and T2 Weighted Fast Spin Echo Magnetic Resonance Sequences for Detection of Multiple Sclerosis Spinal Cord Lesions
Author name:
شيماء فاضل عبيد
Supervisor name:
امير شاكر هادي
General topic:
Medicine
Specific topic:
Diagnostic Radiology
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1376 - p.pdf
Abstract:
Background : Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disease of the CNS of unknown etiology. Age of onset is 20 - 50 years in 50 - 60% of cases, with female propensity. MRI of the spinal cord is thought reliable for investigation lesions. Different techniques and MRI sequences are widely used and compared to each other to improve the detection of MS lesions in the spinal cord. Objective : To evaluate the ability of MRI STIR sequences in improvement of MS spinal cord lesion detection when compared to T2 WI sequences.Patients and Methods : A cross sectional study conducted during the period from 15th of August 2013 to 30th of June 2014. A total of 22 MS patients who had clinically definite MS with clinical features suggestive of spinal cord involvement, and had no contraindication for MRI examination were included. Spinal cord lesions which had artifacts significantly reduce the reading confidence of the images or those which did not show the typical characteristics of MS spinal cord plaques and lesions due to spondyloticmyelopathy were excluded. Patients were imaged with unified MRI protocol for all patients and two MRI sequences were used in imaging; sagittal STIR sequences and sagittal T2 weighted. All images were read by the same radiologist. The study protocol was approved by the ethical committee and the data of the patients were kept confidentially.Results : The mean age of the patients was 32.5 ± 6.7 (range : 23 - 45) years and 54.5% of the patients aged 30 - 39 years. Females were the dominant and represented 72.7% with a female to male ratio of 2.7 : 1. The total number of spinal cord MS lesions was 44,of them 86.4% in the cervical spine, 68.2% of the lesions had less than one vertebra extension,79.6% of the lesions did not associated with changes in the spinal cord morphology. There was a significant upgrading in the lesions conspicuity at STIR sequence comparingto T2 WI, P<0.001. A significant difference had been found in artifact grading between both sequences; P<0.001.Conclusions and Recommendations : STIR MRI sequence improves detection of MS spinal cord plaques compared with T2 WI and it increases the conspicuity of the visualized T2 WI lesions, but also it accentuates the artifacts more than T2WI. The STIR sequence should be included in the standard spinal cord MR imaging protocols and should be obtained routinely with T2 WI. Further studies are suggested.
