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تاثير الجهد التاكسدي على بعض المعايير الدموية وفيتامينات C, D3, E لدى مرضى كثرة الحمر == Effect of Oxidative Stress On Some Hematological Parameters And Vitamin C, D3, And E In Patients With Polycythemia
Author name:
احمد ظاهر محمود الدليمي
Supervisor name:
حميد محمود مجيد | نجاة عبد الرزاق حسن
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
University of Diyala - College Of Education For Pure Sciences - Department Of Biology
Language:
Arabic
University location:
Diyala
First pages:
24T2847 - p.pdf
Abstract:
يتوارد الى مصرف الدم ضمن دائرة صحة ديالى العديد من الاشخاص الذكور, يوميا للتخلص من زيادة الدم (كثرة الحمر) , وللتعرف على بعض جوانب هذه الحالات المرضية : تم جمع 90 عينة دم من هؤلاء المرضى (54 مدخن, 36 غير مدخن) قورنت مع 40 عينة دم لاشخاص اصحاء, تراوحت اعم | Many male persons come every day to the blood bank labeled within Diyala Health Directorate to get rid of blood ratio increase(polycythemia). To shed light on this phenomenon, 90 blood samples are collected from these patients (54 smokers, 36 nonsmokers) and they are compared with 40 blood samples of healthy persons within the age range of (18 - 79 years) in the period ranging from Decembar.1st. 2012 to March.1st. 2013. A Hematocrit (HCT) criterion of 52% is used in the study as a sickness criterion.The present study was conducted to : 1. Measure the red and white blood cells and platelet counts (complete blood picture).2. Measure antioxidant the concentration vitamins C, E in addition to vitamin D3 and Glutathione (GSH).3. Measure the levels of the Malondialdehyde (MDA). Results of the statistical analysis show a significant increase(p<0.001) in Red blood cells, Hematocrit, a significant increase in the White blood cells (p<0.05), a significant increase(p<0.001) in the (Neutrophils, Monocytes and Esophils) while the mean of Lymphocytes and Basophils counts show a significant decrease (p<0.001) compared to the control group. Blood platelet did not show significant variations between the control and sick patient groups. Upon splitting the patients group to smokers and nonsmokers, results of the statistical analysis reflect a significant increase of (p<0.05) in the Hemoglobin of nonsmokers with polycythemia compared to the control group and to smokers. The platelets count did not mirror any significant variations between the patients and control groups despite the increase in platelet numbers in persons with polycythemia group that are nonsmokers and a decrease in smokers patients. Results of the statistical analysis also show a significant increase of MDA levels in patients with polycythemia (p<0.001) compared to the control group especially in the nonsmokers which signals an increase in lipid peroxides and reactive oxygen species. Results of the statistical analysis show a significant decrease of (p<0.001) in the levels of vitamin C in the patients with polycythemia, the smokers as well as the nonsmokers polycythemia sub groups compared to the control group which refers to the notion that the vitamin E free radical attacks vitamin C to remake vitamin E. in this case vitamin C is consumed and vitamin E will be remodeled. There is a significant decrease (p<0.001) in the mean vitamin D3 in patients with polycythemia compared to the control group. Vitamin D3 has an impact on Red and White blood cells inside of the bone marrow, this matter sheds light on the probability of this impact of vitamin D3 on the pathogenesis of polycythemia. The results of statistical analysis did not show significant differences in the means of vitamin E and GSH levels. The present study revealed a positive relationship between vitamin D3 levels and Red Blood Cells counts, In addition there was a negative correlation of vitamin D3 with Mean Corpuscular Volume (MCV) in total polycythemia group and polycythemia smokers sub groups.
