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تاثير العكبر العراقي على مجاميع النتروجين الفعالة (RNS) لدى الجرذان المصابة باعتلال الكلى السكري == The Effect of Iraqi Propolis On Nitrogen Reactive Species In Diabetic Nephropathy Rats
Author name:
امنة ناظم زغير العمري
Supervisor name:
فردوس عباس جابر
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Al-Qadisiyah - College Of Education For Girls - Chemistry Department
Language:
Arabic
University location:
Qadisiyah
First pages:
25T1450 - p.pdf
Abstract:
تضمنت هذه الدراسة تحضير مشتقات حلقية غير متجانسة مثل الامينوبنزوثايازول(aminobenzothiazole) والبايرازول (pyrazole)، والاكسازيبيــــن (oxazipine) , والايميدازوليدين (Imidazolidine) ابتداء من (4 - amino acetophenone) (A0) و(benzidine) (B0) والمركب(2 - ami | This study includes synthsis of new heterocyclic derivatives such as (Thiazole), (Pyrazole), (Oxazipine), and (Imidazolidine), starting from (4 - amino acetophenone) (A0), (benzidine)(B0) and (2 - amino benzothiazole (C).This work is divided into three parts : Part one : Includes synthesis 2 - aminobenzothiazole derivatives (A) and (B) from (4 - amino benzothiazole) (A0) and (benzidine) (B0) respectively ,as starting materials. These steps are explained in diagram (1).diagram (1)Part two : includes two stepsThis part includes two steps : - The first step includes the formation of Schiff bases derivatives for 2 - amino benzothiazole derivatives (A) and (C).While the second step includes synthesis seven 1,3 Oxazpine rings derivatives by reaction with (phathalic anhydride).In addition to, synthesis (Imidazolidine) derivative (A11) from the reaction with ? - Alanine. These steps are explained in diagrams (2) and (3).diagram (2) diagram (3)Part three : includes two steps The first step includes preparation Azo derivative (A12) by reaction of (acetyl acetone) with the compound (A) (6 - acetyl - 2 - amino benzothiazole) , then (A12) was entered the reaction of cycliczation with hydrazine hydrate or their derivatives to formate various five pyrazole rings derivatives. These steps are explained in diagram (4).diagram (4)The Sequence of reactions steps are followed up by (TLC) technique, and by using solvents (methanol or acetic acid and benzene ( 1 : 4 )). All compounds are identified by (FT - IR) ,and some compounds by 1H - NMR and (C.H.N.S).
