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تاثير الاصابات المجهرية المهبلية وبعض الهرمونات على الاصابة بالمشعرات المهبلية عند النساء في بعقوبة - محافظة ديالى == Effect of Microbial Vaginal Infections And Some Hormones On Trichomonas Vaginalis Infection In Women In Baquba - Diyala Province
Author name:
حنان رحيم حسوني الخشالي
Supervisor name:
نغم ياسين كاظم البياتي
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
University of Diyala - College Of Education For Pure Sciences - Department Of Biology
Language:
Arabic
University location:
Diyala
First pages:
24T2887 - p.pdf
Abstract:
: توجد هناك عدة عوامل تلعب دور مهم في زيادة الاصابة بطفيلي المشعرات المهبلية وهذه العوامل تتضمن : اختلال مســـــتوى الهرمونات الجنســـــية, تغير الرقم الهيدروجيني للمهبل, بعض انواع الاصابات البكتيرية.الهدف من الدراسة : اولا : تحديد نسب وانواع الاصابات ال | Introduction : It have been founded that many factors play important roles in the increase incidence of infection with Trichomonas vaginalis these factors includes : disturbances in sex hormones level, change in pH of vagina and some types of bacterial infections.Aims : First : To determine the rates and types of Microbial vaginal infections that infected women in Baquba - Diyala province.Second : study of the relationship between the Trichomonas vaginalis and other microorganisms.Third : study the relationship between the Trichomonas vaginalis and the levels of some sex hormones.Patient and Methods : This study was carried out on 227 patients attended either Al - Batol Teaching Hospital for Maternity and Children in Baquba - Diyala, or some private clinic in Baquba city, most of these patient giving symptoms of vaginitis as a patient group, in addition to 10 healthy women as a control group.Patients group included married, widows and divorcees women with age range between (18 - 45) years, and at different educational level.Full clinical evaluation was done for those patient including history and physical examination. This evaluation revealed that 209 of patients (92%) had vaginal discharge, irritation and itching. Reguested blood samples were taken for laboratory test included estradiol, progesterone and testosterone. The level of these sex hormones in women with Trichomoniasis have been determined and compared with levels of these hormones in control group.In addition high vaginal swab were taken for microbiological tests. and used for diagnosis of Trichomonas vaginalis and other associated microorganisms, the rate of parasitic infection had been determined and it's relation with age group, marital status, level of education and level of vaginal acidity had been estimated. Moreover, the percentage of cases, with pus cells, epithelial cells, red blood cells and clue cells have been estimated. Results : the results of laboratory tests elicited the presence of Trichomonas vaginalis (6.3%). And in addition to it there is bacterial and fungal vaginal infection and the percentages were (54%) and (15%), respectively. Moreover, the results showed the presence of dual infections between the parasite and bacteria, the parasite and fungi, and bacteria and fungi and there percentages were (11.8 %), (8 %) and (4.9 %), respectively.Regarding age group, results showed that the highest parasite infection rate was among women in the age group (26 - 35 years) which was (41.1%), in compare with infection rate in others age group (18 - 25 years) and (36 - 45 years) which were (9.3 %) and (18 %), respectively. Regarding, the marited status, the highest infection rate was founded among married women in comparison with widows, divorcees women, and the percentages were (31.7 %), (6.8 %) and (14.7 %), respectively. Regarding, the educational level, the results showed highest rate of infection with Trichomonas vaginalis was among women with low educational level which was (11.8%) in compared with those with intermediate (7.9%), secondary (4.8%), and tertiary education (1.3%). Regarding, the pH of the vagina, results showed that the rate of vaginal infection were high when pH of vagina > 4.5 in comparison with the lowpH ? 4.5 and the percentages were (83.7%) and (16.3%), respectively. The results of direct smear and cultures showed that (25.9 %) of case (59 patient) were infected with Trichomonas vaginalis, (31.7%) of case infected with E.coli, (27.7%) of case infected with candida albicans, (21.1%) infected with Gardnerella vaginalis, (17.6%) percentages of Lactobacillus spp. (8.3%) percentages of Staphylococcus epidermidas (5.2%) in fected with S. aureus, (3.5%) infected with Enterobacter spp., (2.6%) infected with Proteus spp., (2.2%) infected with Klebsiella spp., (1.7%) infected with Acentobacter spp. and Streptococcus spp., (1.3%) infected with Pseudomonas spp., While the lowest rate was for Neisseria gonorrheae (0.8%). Also results showed that the highest percentage of dual infection with trichomoniasis it was in Gardnerella vaginalis which detected in 22 case (37.2%), followed by Candida albicans, which detected in 18 case (30.5%). While the lowest rate was with Neisseria gonorrheae which detected in one case (1.6%). The other laboratory tests including hormonal estimation in patients with trichomoniasis, the results of current study showed decrease level of estradiol hormone in women infected during follicular and luteal phases of the menstrual cycle, In follicular phase the mean of estradiol was (6.83 pg/ml) in comparison with control group that hormone rate was (42.61 pg/ml). In luteal phase the mean of estradiol was (27.00 pg/ml) comparison with control group which hormone rate was (87.16 pg/ml). In addition to that the level of progesterone have increased in follicular phase but decreased in luteal phase in comparison with control group. In follicular phase the mean of progesterone was (5.89 ng/ml) in com - parison with control group which hormone rate was (0.72 ng/ml). In luteal phase the mean of progesterone in infected women was (0.56 ng/ml) comparison with control group in which hormone rate was (19.83 ng/ml).Regarding, the level of testosterone, the results showed that the level had been increased during the follicular and luteal phases in infected women compared with control group. In follicular phase the mean of testosterone was (3.44 ng/ml) in comparison with control group which the mean was (0.24 ng/ml). In luteal phase the mean of testosterone was (3.65 ng/ml) in comparison with control group in which the mean was (0.30 ng/ml).Conclusion : The presence of infection with Trichomonas vaginalis, and it's associated with other microorganisms that are detected in the current study and other study previous may indicated a correlation between them. So those patient, constantly in need for a panel of laboratory test including : vaginal pH, and hormonal estimation as these factors may play a role in diagnosis and follow - up of the patients.
