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مستوى المستند المصلي الخاص بالبروستات مقارنة مرضية سريرية للنساء المصابات بسرطان الثدي == Serum PSA level with Clinicopathological Correlation in women with breast cancer
Author name:
ايناس عبد المجيد رشيد
Supervisor name:
يعرب ادريس خطاب
General topic:
Medicine
Specific topic:
Diseases
Degree:
Master
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1419 - p.pdf
Abstract:
Prostate - specific antigen (PSA) is a serine protease expressed at high levels in prostate epithelium & elevated PSA in serum is well established marker of prostate cancer. Recently, the relative proportions of free PSA & PSA complexes to α1 - antichymotrypsine have become important variables in distinguishing between prostate cancer & benign prostatic hyperplasia (BPH). Numerous studied have demonstrated the production of PSA in female tissues e.g. breast & low levels of PSA are present in female sera.In this prospective study, we measured the levels of total PSA by mini VIDAS machine in the sera of 45 newly diagnosed breast cancer female patients & correlated these with selected clinicopathological variables includes : - Patient’s age, menopausal status, tumor size & volume, histological type & grade of the tumor , lymph node status & steroid hormone receptor status.The detected level of total PSA in the sera of healthy control was <0.07 ng/ml. About 35.6% of the total cases of women with breast cancer showed a higher levels (≥0.07 ng/ml) of total serum PSA.Chi - square & T - tests were used to identify the significance of association between total serum PSA levels & the clinicopathological variables. However, it has been found a significant association (P<0.05) between the level of total serum PSA & patient’s age, menopausal status, lymph node status & steroid hormone receptors (estrogen/ progesterone receptors).On the other hand, it has been identified there was no significant association (P>0.05) between the levels of total serum PSA & tumor size & volume, & histological type & grade of the tumors.We concluded that total serum PSA cannot be used as a screening program for early detection of breast cancer, but may be useful in close follow up the patients & may have a prognostic guide to response to the type of treatment.According to the results of our study, we recommend further study include larger sample size, combination of total serum PSA with other tumor marker.
