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انتشار متلازمة شيغرن الثانوية لدى عينة من المرضى المصابين بداء الذاب الحمامي المجموعي == Prevalence of Secondary Sj?gren’s Syndrome in a Sample of Patients with Systemic Lupus Erythematosus
Author name:
نور عباس
Supervisor name:
سامي سلمان شهاب
General topic:
Medicine
Specific topic:
Diseases - Joints
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1330 - p.pdf
Abstract:
Background : Systemic lupus erythematous is a common autoimmune disorder occurring predominantly in women during reproductive years, the hallmark of SLE is its diversity of presentation with accumulation of manifestations over time and undulating disease course. Sj¨ogren’s syndrome (SS) is a chronic autoimmune disease that characteristically affects salivary and lacrimal glands such that patients have severe dry eyes and dry mouth. The disease may also involve numerous other organs, including the lungs, kidneys, joints, skin, peripheral nerves, and brain. Objective : To assess the prevalence of secondary sjogren syndrome in SLE patients.Patients and Methods : This cross sectional study involved a total of 50 patients with SLE diagnosed according to the revised American College of Rheumatology classification criteria, Sociodemographic data and medications were recorded. Disease activity for SLE was assessed with the SLE Disease Activity Index Case histories and personal information were assessed : age, SLE disease duration, body mass index, all subjects were screened for secondary Sj¨ogren’s syndrome by American - European Consensus Group Classification Criteria for Sj¨ogren’s Syndrome.Results : Prevalence of secondary Sj¨ogren’s syndrome in SLE patients was (8.4%). SLEDA was significantly higher in patients with Sj¨ogren’s syndrome (100%), there was no important or statistically significant correlation of all variable including disease duration, age, White blood cell count, Hemoglobin, Platelet count, antinuclear antibodies and anti - double Deoxyribo nucleic acid antibodies and the decrease in complement (C3 and/or C4) with secondary Sjogren’s syndrome. The anti - LA was statistically higher in patients with Sj¨ogren’s syndrome.Conclusions : The prevalence of secondary Sj¨ogren’s syndrome among SLE patients was relatively low. SLE disease activity as well as Anti SSB was significantly higher in patients with secondary Sj¨ogren’s syndrome
