Share
التاثيرات السمية المرضية للسايبرمثرين على بعض المعايير الكيموحيوية, وفعالية الاستايل كولين في الجرذان البالغة == Toxicopathological Effects of Cypermethrine On Some Biochemical Parameters And Acetylecholine Activity In Sprague Dawley Rarts (Ruttus Norvegicus)
Author name:
طلال جبل حسين
Supervisor name:
زينب وحيد خضير | صالح كاظم مجيد
General topic:
Veterinary Medicine
Specific topic:
Veterinary Medicine
Degree:
Master
University:
University Of Basrah - College Of Veterinary Medicine
Language:
English
University location:
Basrah
First pages:
21T512 - p.pdf
Abstract:
اجريت الدراسة الحالية في البيت الحيواني التابع لكلية الطب البيطري في جامعة البصرة لتقييم التاثير السمي للجرع المختلفه للسايبرمثرين على الدماغ والحبل الشوكي والعصب الوركي والكبد والكلية والخصية اضافة الى تاثيره على انزيمات الكبد(AST,ALT) وانزيمات الكلية (ا | The present study was conducted in the laboratory animal house - college of veterinary medicine - University of Basra to investigate the Toxicological effects of different doses of Cypermthrin on Brain, Spinal cord ,Sciatic nerve, Liver, Kidney ,and Testis and also its effect on liver enzymes (ALT and AST), kidney enzymes (urea and creatinine) ,and serum acetylcholine (Ach) in adult Sprague dawley rats (Rattus norvegicus). Fourty eight adult rats were used , they were divided randomly and equally into four groups. Control group orally dosed with normal saline for 90 days. The other three groups were dosed orally with different three doses of cypermthrin , high dose ( 64 mg / kg b.w. ) intermediate dose ( 32 mg / kg b.w. ) and low dose ( 16mg / kg b.w. ). The results showed that there were hitopathological changes of brain, spinal cord and Sciatic nerve that revealed there were a dose dependent increase in vaccuolation in nerves fibers to be affect larg number of nerve fiber in high dose and also affected few numbers of nerve fibers in low dose. Also there were changes in liver ,kidney and testis. Serum AST, ALT, urea, creatinine and acetylecholine concentrations increased significantly ( p ? 0.05) in rats exposed to cypermethrin in comparisons with control. In conclusion cypermthrin affects positivly on histopathological findings of nervous system, liver tissues and enzymes, kidney tissues and enzymes ,and Acetylcholine (Ach) neurotransmitter.
