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تحضير وتشخيص بعض مركبات N - Oxide جديدة ودراسة فعاليتها الحيوية == Synthesis and characterization of some novel N - Oxides and Study their Biological activities
اسم المؤلف:
نور عبد الخضر سلمان الاميري
اسم المشرف:
ماجد حمود الصافي | محمد عجه عوده
الموضوع العام:
علوم الكيمياء
السنة:
2016
الموضوع الدقيق:
الكيمياء
الدرجة:
ماجستير
الجامعة:
جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة:
العربية
مكان الجامعة:
ذي قار
المستخلص:
In this study, we prepared a series of nitrones compounds resulting from the interaction of azo dyes prepared which contain Carbonyl edge with hydroxylamine compound . | It was prepared a series compounds of azo dyes (A1, A2, A4, A5) have been prepared by the reaction between 2- amino pyrimidine with diazonium salts which contain benzaldehyde derivatives(4-hydroxy benzaldehyde, 4- chloro benzaldehyde, 4-dimethylamino benzaldeyde, 2- nitro benzaldehde). While the compound A3 was prepared by the reaction between 6-amino-2-mercaptopyrimidin-4-ol with 4-hydroxy benzaldehyde.It was also prepared two groups of Nitrones, the first | group includes the compounds (B1, B2, B3, B4, B5) resulting by the reaction between azo dyes prepared (A4, A2, A5, A1, A3) respectively with N-phenyl hydroxylamine. | On the other hand the second group includes the compounds( C1, C2, C3) resulting by the reaction between azo dyes (A4, A2, A1) respectively with NParatolyl hydroxyl amine Those compounds have been confirmed the authenticity | of the molecular structures of the compounds prepared | using the TLC, infrared spectroscopy and 1H-NMR | spectrum and 13C-NMR spectrum. | It has also been study the toxicity by the calculation of the median lethal dose LD50 of one of the prepared Nitrone compound B1 on laboratory rats , the result was that the prepared compound was non toxic at the used doses ( 34.2-136.8 ) . | We also study the biological activity of the prepared compounds ( Alaldehydes and Nitrones ) by observing its effect on negative and positive bacteria of gram dye
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