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انتشار اكتناف العين لدى عينة من المرضى العراقيين المصابين بالتصلب المجموعي == Prevalence of Ocular Involvement in a Sample of Iraqi Patients with Systemic Sclerosis

اسم المؤلف: زينة يحيى جواد

اسم المشرف: فائق ايشو كوريال

الموضوع العام: الطب

السنة: 2015

الموضوع الدقيق: الامراض - المفاصل

الدرجة: دبلوم عالي

الجامعة: جامعة بغداد - كلية الطب

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى: 📎 19T1497 - p.pdf

المستخلص: Background : Systemic sclerosis (scleroderma, SSc) is a severe systemic chronic connective tissue disease. Many ocular manifestations of SSc have been described, some being well - known associations and others reported for the first time in case reportsObjectives : The aim of this study was to evaluate the prevalence and characteristics of ocular manifestations in a sample of Iraqi patients with SSc.Patients and methods : This cross - sectional study involved 50 patients with SSc diagnosed according to 2013 criteria developed by the American College of Rheumatology/European League Against Rheumatism for the classification of systemic sclerosis or the 1980 classification criteria for SSc, established by the American Rheumatism Society (now the American College of Rheumatology). Patients had history of previous eye trauma, hypertension, diabetes mellitus, and overlap with other connective tissue diseases or inflammatory arthritis were excluded. Demographics and clinical data were collected including age, sex, BMI, disease duration and subtype, age at diagnosis, scleroderma assessment questionnaire (SAQ), medications used, blood investigations and autoantibody profile were collected, and a full ophthalmic examination was conducted. Results : A total of 50 patients with systemic sclerosis (SSc) were enrolled in this study. Prevalence of dry eye symptoms was 74%, keratoconjunctivitis sicca (KCS) was 68%, eyelid skin stiffness and telangiectasia were observed in 56% and 36% respectively. Refractive errors were detected in about a quarter of cases (24%). Myopia was the most frequently identified type of refractive errors (18%), followed by astigmatism (6%) and hypermetropia (only 2% after excluding the age dependent presbyopia). Blepharitis was diagnosed in 18% of examined patients. Each of the following ocular manifestations, namely : subcapsular cataract, pterygium, conjunctival abnormalities, cataract - cortical type, uveitis (Anterior or posterior) and retinal microvascular abnormality were detected in less than 10% of cases. Positive serum anti - scleroderma 70 (anti - scl 70) antibodies significantly increased the risk of having KCS . also diffuse disease type significantly increased the risk of having eyelid skin stiffness . There were no significant correlation between patients with KCS, refractive error and eyelid skin stiffness with the other variables .Conclusions : Ocular manifestations in a sample of Iraqi patients with SSc were relatively common. The most common SSc - related ocular findings were dry eye symptoms, then KCS, followed by eyelid skin thickening and telangiectasia.