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تقدير البروتينات الدهنية والاجهاد التاكسدي في مصل المصابين بمرض حب الشباب == Evaluation of Serum Lipid Profile and Malondialdehyde in Patients with Acne

اسم المؤلف: رنا عبد العالي الرفيعي

الموضوع العام: علوم الكيمياء

السنة: 2008

الموضوع الدقيق: الكيمياء التحليلية الحياتية

الدرجة: ماجستير

الجامعة: جامعة الكوفة - كلية التربية للبنات - قسم الكيمياء

اللغة: الانكليزية

مكان الجامعة: النجف

الصفحات الاولى: 📎 25T1564 - p.pdf

المستخلص: The present study was conducted to verify the relevance of lipids and lipoproteins levels and their byproduct of oxidation, malondialdehyde (MDA) in acne patients. The design of the project included one hundred acne patients (47% males and 53% females)and 40 apparently healthy individuals (control group). Total serum cholesterol (TC), high density lipoprotein cholesterol (HDL - C), triglycerides (TG), low density lipoprotein (LDL - C), very low density lipoprotein (VLDL - C) and MDA levels were measured in acne patients and the control group.The results indicated significant (P≤0.05) elevations for TC, TG, LDL - C, VLDL - C and MDA levels in acne patients with respect to those of the control group. Sex differences were obtained as rises forTC, LDL - C and MDA (P≤0.05) in males when compared with thoseof the females. The linear regression analysis exhibited significantpositive correlation for TC (r = 0.68, P≤0.05) and LDL - C (r = 0.48, P≤0.05) with ages of the control group but not in the acne patients.Smoker acne patients demonstrated significant elevations for TC, TG, VLDL - C, LDL - C and MDA (P≤0.05) in comparison with those of the control group, while nonsmokers acne patients showed significant elevations for TC and LDL - C (P≤0.05) during a comparable evaluation. Married acne patients indicated significant increases for TC, TG, VLDL - C, LDL - C and MDA (P≤0.05) when compared with those of the control group, while non married acne patients illustrated significant elevations for TG, VLDL - C, LDL - C and MDA (P≤0.05). The influence of treatment was studied, the data stated significant elevation for TG and LDL (P≤0.05), in treated acne patients when compared with those of the control group, while untreated acne patients showed significant increases for TC, TG, VLDL - C, LDL - C and MDA (P≤0.05) in comparison with those of the control group.These results suggested that oxidative stress is involved in the pathogenesis of acne. We believed that this study is the first to deal with changes of serum lipid profile and oxidative stress in acne patients.