تحضير وتشخيص ودراسة الفعالية البايولوجية لمشتقات جديدة من 4.3.1 اوكسادايازول ومعقداتها مع بعض العناصر الانتقالية == Preparation , characterization and biological activity of a new1,3,4 - oxadiazole derivatives and some of their transition metal complexes
Author name:
ايمان حسين شويل التميمي
Supervisor name:
ابراهيم عبود فليفل | احمد حسن محمد
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Thi-Qar - College Of Science - Chemistry Department
Language:
Arabic
University location:
Dhi Qar
Abstract:
The work described in this thesis is mainly concerned with preparation and characterization of three ligands (L1-L3) derived from 1,3,4-Oxadiazole .The study deals with reaction of these ligands with transition metal salts as (CrCl3.6H2O , CoCl2.6H2O , NiCl2.6H2O , CuCl2.2H2O) .The ligands and their complexes were characterized by the elemental analysis (C,H,N), Infrared spectroscopy (IR) , Proton Nuclear Magnetic Resonance Spectroscopy (1HNMR), Mass spectra and molar conductivity. However, the ligands and some of their were studied by using hyperchem7.5 program in order to know their geometry and proving their shapes and hypridizaion which were notice the chromium complexes is octahedral (oh), the hypridization is d2sp3 with the three ligands while the shapes of the complexes (cobalt(II), Nickel(II), Cupper (II) ) is four coor-dinated is square planar and the hypridizaion is sp3. | Antibacterial activity was carried out against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes and Klepsiella pneumonia, and with test compounds at four concentrations of (5, 2.5, 1.25, 0.625mg/ml). Azithromycin and Cefoaxime were the standard drugs utilize. Some of these compounds showed good efficacy, while others ranged from medium to small. | The hemolysis activity of the compounds was tested at different concentrations (5, 2.5, 1.25, 0.625mg/ml) and the results showed high percentage of hemolysis for all these compounds and these gave a conclusion about the contraindication use of these compounds in vivo .
