قياس كثافة معدن العظم ومستوى فيتاميهن د في عينة من المرض العراقيين المصابين بمرض بهجت == Bone Mineral Density and Serum Vitamin D Level in A Sample of Iraqi Patients with Behcet’s Disease
Author name:
نور حسن عبد الرسول
Supervisor name:
نزار عبد اللطيف جاسم
General topic:
Medicine
Specific topic:
Diseases - Joints
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1431 - p.pdf
Abstract:
Background : Behcet’s disease (BD) is a multisystemic vasculitis characterized by recurrent orogenital aphthous ulcers , uveitis and skin lesions with chronic relapsing course. The chronicity and vasculitic background of Behcet's disease (BD) and the drugs used for its treatment may result in low bone mineral density. Low serum vitamin D status is closely associated with disease risk of BD.Aim of the study : To evaluate if there is a change in bone mineral density (BMD) and vitamin D level in Iraqi patients with BD.Patients and methods : In this case control study a forty two BD patients who were diagnosed according to International Study Group Criteria, and a total of 24 healthy persons recruited as a control group were enrolled in the study.Patients with histories of chronic disease affecting bone metabolism were excluded from the study. All female patients were premenopausal women.All BD patients and control group were subjected to detailed history taking & thorough clinical examination. Weights and heights of all subjects were recorded and body mass index (BMI) was calculated. A signed consent was taken from the individuals in both groups for admission in the study.Venous blood samples were obtained from all patients and controls for complete blood count, erythrocyte sedimentation rate (ESR), C - reactive protein (CRP), total serum calcium, total serum phosphorus and total serum alkaline phosphatase. Total serum 25 - hydroxyvitamin D (vitamin D) was assessed and levels ≥22 ng/ml were considered sufficient, while levels of <22 ng/ml were considered low. Bone mineral density measured in the lumbar spine (L2 - L4) and right femur neck using dual - energy x - ray absorptiometry (DXA) machine were performed.VIIResults : The mean age for BD patients was 34.2±9.6 years compared to 31.8±6.5 years in control group. Male represented 69% in BD and 70% of healthy controls. Mean disease duration for BD was 5.9±6.7 years.The mean BMI of BD patients was 27.1±4.5 Kg/m2 compared to 27.4±3.5 Kg/m2 in controls.The personal and clinical characteristics of study sample show no clinical significant difference between patients and controls apart from current smoking which was significantly associated with BD (P < 0.05). Osteoporosis and osteopenia that are found by T score at both spine (L2 - L4) and right femur neck were significantly higher in patients with BD (P<0.05). Serum vitamin D levels were significantly lower in patients with BD than controls (P<0.001). Serum vitamin D levels were significantly inversely correlated with BD duration.Conclusion : Osteoporosis, osteopenia and lower serum vitamin D levels are significantly more common in BD patients compared to controls.
