دراسات ثرموداينميكية وحركية لفعالية مركبات متعدد الفينولات الطبيعية للوقاية من التسمم بالرصاص == Thermodynamic And Kinetic Studies On The Effectiveness of Nutritional Origin Poly Phenols In Lead Poisoning Protection
Author name:
نجدت رضا حميد علي الخفاجي
Supervisor name:
الهام مجيد الرفيعي
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Baghdad - College Of Science - Chemistry Department
Language:
English
University location:
Baghdad
First pages:
25T1434 - p.pdf
Abstract:
يتضمن البحث تحضير مركبات حلقية غير متجانسة جديدة ( خماسية , سداسية وسباعية )ودراسة الفعالية الحيوية لها.المرحلة الاولى : تتضمن مفاعلة بنزين ثنائي الامين مع ثنائي كبريتيد الكاربون في الايثانول المطلق للحصول على المركب [1] ليتفاعل مع ( حامض الماليك , حام | This research involves synthesis of new heterocyclic compounds(five , six , and seven - membered rings) and study their biological activity First Part : The o - phenylenediamine was condensed with carbon disulfide in abs. ethanol to yield compound [1] which reacted with(maleic acid and oxalic acid ) and presence of phosphorus oxychlorid to yield compounds [2,3].Second Part : The phthalic anhydride was condensed with glycine in aceton to give compound [4] which reacted with o - phenylenediamine in presence of phosphorus oxychlorid to give compounds [5] and with o - phenylenediamine in abs. ethanol to give compound [6] which reacted with maleic acid in presence of phosphorus oxychlorid to give compound [7]. Third Part : Thiosemicarbizide was condensed with carbon disulfide in abs. ethanol and presence of sodium carbonate to result compound [8] which reacted with different sugars (ribose , xylose and arabinose) in abs. ethanol and presence of glacial acetic acid to give new Schiff bases derivatives [9 - 11] respectively. The resulting imine derivatives were reacted with ( salicylic acid , 2 - mercaptobenzoic acid and glycine) to give compounds [12 - 14] respectively.Fourth Part : Study of biological activity of some synthesized compounds
