العلاقة المحتملة بين مرض الاكياس المائية وسرطان الكبد والرئتين == The Probable Relationship Between The Hydatidosis And Liver And Lungs Cancer
Author name:
ايمان سلمان خميس محمود
Supervisor name:
ندى محمد طه البشير | نغم ياسين البياتي
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
University of Diyala - College Of Education For Pure Sciences - Department Of Biology
Language:
Arabic
University location:
Diyala
First pages:
24T2909 - p.pdf
Abstract:
تعد الاصابة ببعض العوامل المرضية مسؤولة عن حوالي خمس حالات السرطان في العالم. وهنالك العديد من الاصابات الطفيلية التي ثبت دورها كمسبب او محفز لسرطانات معينة، الا ان العلاقة بين الاصابة بالاكياس المائية والسرطان مازالت موضع جدال ولذلك فقد هدفت الدراسة الح | Infectious agents are responsible for about one fifth of all cancer cases worldwide. Some parasitic infections are well documented to cause certain cancers. However, the association of hydatid cyst (HC) with cancer is a controversial issue. The current study aimed to investigate the possible association between chronic hydatid cyst infection with liver and lung cancers. The study involved three groups : the first group included 42 patients with HC, the second group included 35 patients with liver (12) and lung (23) cancers, while 25 apparently healthy individuals were recruited to represent the third group (control). Number, diameter, location and the status (calcified or non - calcified) of the HC were recorded from HC group. Blood samples were collected from the studied groups from which serum were separated and kept until being used. Enzyme linked immune - sorbent assay (ELISA) was used to estimate serum levels of anti - HC IgG antibodies, carbohydrate antigen (CA19 - 9), alkaline phosphatase (ALP) and ? - glutaml transferase (GGT), while Absorbance measured by spectrophotometric method was used to determine levels of lactate dehydrogenase (LDH) and adenosine deamimase (ADA).All members of HC group gave positive result for anti - HC IgG antibodies compared to 11 patients from cancer group and oneindividual from control group (Odds ratio =8.3). Both HC and cancer groups showed significantly higher p<0.05 levels of CA19 - 9, ALP, LDH and GGT ((76.16±58.26 U/ml and 110.77±96.47 U/ml), (131.81±76.65 U/L and 141.72±97.23 U/L), (244.24±117.94 U/L and 254.68± 115.56 U/L) and (95.06±66.73 U/L and 105.12± 41.42 U/L) respectively) than control group (10.81± 9.12 U/ml, 65.14± 25.21 U/L, 146.15± 37.59 U/L and 17.21± 6.87 U/L respectively). In cancer group, casp - 8 level (72.20±54.72 picomol/ L) was significantly lower from than that of control group (92.30± 41.20 picomol/L) and insignificantly from that of HC group (60.86±40.84 picomol/L). In HC group, ADA level was 47.84±10.65 U/L and was significantly higher p<0.05 than that of cancer group (10.14± 1.99 U/L) and control (16.09±2.70 U/L).Investigation for the risk factors which may increase the risk of developing liver or lung cancers in HC patients revealed that male, smokers and rural residents were more susceptible for such development (Odds ratios : 3.45, 6.982 and 5.48, respectively). Number and cyst size were significantly correlated with the level of anti - HC IgG antibodies (r= 0.539, P<0.001 and r= 0.618, P< 0.001 respectively), while calcified cysts associated with significantly higher levels p<0.05 of CA19 - 9 and GGT (105.03±88.9 U/ml and 145.46±101.57 U/L, respectively) than that of non - calcified cysts(65.91±39.87 U/ml and 77.17±7.23 U/L, respectively). Average level of anti - HC IgG antibobodies in calcified cysts was 19.75±13.11U/ml and was significantly P<0.05 lower than its counterpart of non - calcified cysts (85.017±76.84 U/ml). All studied parameters showed significantly higher levels in livers cysts than their counterparts in lung cysts. Results of the current study indicate that chronic infection with HC can increase the host susceptibility to develop liver or lung cancer.
