دراسة المضاعفات الفموية الوجهية, مؤشرات عامل - الغلوبيولين المناعي اللعابي A , الانترليوكين 6 وعامل تنخر الورم الفا في لعاب مرضى بيتا ثلاسيميا الكبرى في محافظة ميسان == Study of Orofacial Complications, Salivary IgA, Interleukin - 6 And Tumor Necrosis Factor - Alpha Markers In Saliva of Beta - Thalassemia Major Patients In Missan Governorate
Author name:
جمال محبس ديوان
Supervisor name:
زاهدة جاسم محمد
General topic:
Dentistry
Specific topic:
Dentistry
Degree:
Master
University:
University of Baghdad
Language:
English
University location:
Baghdad
First pages:
20T375 - p.pdf
Abstract:
الثلاسيميا نوع بيتا هو الاضطراب الاحاد اليين الاكثر شيوعا في الشرق الاوسط، والتي تتميز بشذوذ في تركيب سلاسل بيتا من خضاب الدم مما يؤد الى ظواهر متفاوتة تتراوح بين فقر الدم الشديد الى عدم وجود اعراض سريريا.اهداف الدراسة : تحديد مدى انتشار المضاعفات الفمو | Beta - thalassemia is the most common monogenic known disorder in the Middle East, characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic Individuals. Several immunological defects can be found in patients with beta - thalassemia major patients, among which circulating cytokines levels, impairment of neurophil, macrophage phagocytic and killing functions, this impairment may be due to iron over load.Aims of study : Aims of this study was to evaluate the prevalence of Orofacial complications in beta - thalassemia major patients, salivary flow rate, salivary levels of salivary immunoglobulin A, interleukin - 6 and tumor necrosis factor alpha and to evaluate correlations between salivary parameters (salivary immunoglobulin A, interleukin - 6, tumor necrosis factor alpha and salivary flow rate) in beta thalassemia major patients.Methods : Sixty subjects were participated in this study, they were divided into two groups, patients group composed of 30 patients with major beta - thalassemia, age rang (5 - 23), and 30 healthy looking subjects of both sexes as a control group, age rang (5 - 25). Data was collected using a special formula for general, medical and Orofacial examination sheet. Whole non - stimulated saliva was collected, measured and analyzed by enzyme linked immmunosorbent assay.Results : Most patients were in the first and second decade of life (90%), 20 (60%) were males and 10 (40%) were females with an age rage (5 - 23 years). The prevalence of Orofacial complications in beta - thalassemia major patients increased with age.The prevalence of orofacial complications in beta - thalassemia major patients were color change of oral mucosa (73.3%), rodent face (66.7%), maxillaryprotrusion (66.7%), saddle nose (63.3%), deep bite (26.7%)), open bite (13.3%) and spacing (10%).Regarding the salivary flow rate there was a statistically significant decrease in mean of salivary flow rate in patients group as compared with control group (P= 0.013).Laboratory investigations for salivary concentration of interleukin - 6, tumor necrosis factor alpha and salivary immunoglobulin A revealed highly significant to significantly in mean of these parameters in beta thalassemia major patients as compared with control group, interleukin - 6 (p=0.001), tumor necrosis factor alpha (p= 0.01) and salivary immunoglobulin A (p= 0.05) at P value ? 0.05.Conclusions : Beta - thalassemia major patients have specific Orofacial complications and a particular salivary cytokines compared to normal individuals.
