اضطرابات الغدة الدرقية في مرضى الذئبة الحمامي المجموعي
Author name:
هند عدنان محمد
Supervisor name:
خضير زغير معيوف البدري
General topic:
Medicine
Specific topic:
Diseases - Joints
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1550 - p.pdf
Abstract:
Thyroid hormone abnormalities had been shown to be more frequent in patients with systemic lupus erythematosus (SLE), hence, performance of thyroid function tests in patients with SLE, as a part of the biochemical and immunological profiles, may help in early detection of associated thyroid disorders.Aim of the Study : To assess the thyroid hormone abnormalities in a group of systemic lupus erythematosus Iraqi patients.Patients and Methods : A case - control study was conducted at Baghdad Teaching hospital, Department of Rheumatology during the period from September 2016 to July 2017. Including 58 SLE patients and 60 controls who met the inclusion criteria. After ethical approval, data were collected using a preconstructed data collection sheet, questionnaire included demographic and clinical data of the patients and controls. Thyroid function tests, complete blood count, ESR, anti - double - strand DNA and complement C3 and C4 test were performed. Statistical analysis was done using the statistical package for social sciences (SPSS) v.24.Results : The mean age of the studied groups was 28.26 ± 7.1 years and 29.18 ± 6.3 years in SLE and control groups, respectively. No statistically significant differences between both groups had been found in age, BMI, or other demographic variables (P>0.05). Abnormal thyroid function was significantly more frequent in SLE patients (25.9%) than controls (5%), (P< 0.05). Primary hypothyroidism and Subclinical hypothyroidism were the more frequent disorder in SLE patients; 6/15 nd 5/15, respectively, each of subclinical hyperthyroidism and primary hyperthyroidism was reported in 2/15 SLE patients. Prednisolone and Hydroxychloroquine were the more frequently used medications among the SLE patients and were insignificantly associated with abnormal thyroid function in SLE patients, (P>0.05). High ESR was reported,, Leucopenia , high Anti dsDNA , low C3 and low C4 and Lymphopenia were reported in SLE patients. While all of SLE patients were ANA +ve and none of them had thrombocytopenia.Conclusions : Thyroid dysfunction was more frequent in SLE Iraqi patients compared to healthy population and the primary hypothyroidism and subclinical hypothyroidism were the more frequent types.
