اثر التطبيق الموضعي من الكركمين مسحوق وزيت اساسي على التئام جروح الجلد : دراسة نسيجية وكيميائية نسيجية مناعية في الارانب == Evaluation The Effect of Topical Application of Curcumin Powder And Essential Oil On Skin Wound Healing In Rabbits (Histological And Immunohistochemical Study On IGF - 1R)
Author name:
نضال حسين محمد
Supervisor name:
بان عبد الغني جميل
General topic:
Dentistry
Specific topic:
Oral Histology
Degree:
Master
University:
University of Baghdad
Language:
English
University location:
Baghdad
First pages:
20T380 - p.pdf
Abstract:
خلفية الموضوع : طب الاعشاب يمكن ان يعرف كواحد من فروع الطب باشكال مختلفة. وقد اثبت كركمين الكركم فعاليته كماده ملونة، ومنكهة واستخدم تقليديا في الطب،فقد اظهر له خصائص ملحوظه مضادة للالتهابا ت، مضادات الاكسده وخصائص بيولوجية متنوعة.ان عدم وجود سمية للكركم | Back ground : Herbal medicine can be called one of the branches of medicines in various forms.Turmeric curcumin has proved it's efficiencies a coloring, flavoring agent and has been traditionally used in medicine, exhibiting remarkable anti - inflammatory, and antioxidant properties. The varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive toexplore its use in various disorders like diseases of skin.It is good potential agent for wound healing.Considerable interest has been focused on curcumin compound, mechanisms that drive wound repair are complex and have challenged wound - healing investigators for many years.Aims of the study : To evaluate the effects of topical application of curcumin (powder and essential oil)on skin wound healing histologically and immunhistochemically.Materials and methods : Sixty four New Zealand rabbits were used in this study, they were divided into four groups (16 animals for each healing period)each group was subdivided as follows : - Experimental groups(8 rabbits)subdivided into : a - Right facial side of(eight rabbits animal) for essential oil application Left facial side of(eight rabbits animal)for curcumin powder application - Control group (eight rabbits)(right facial sides used as control). Histological evaluation of wound healing was performed for all studied groups.Imunohistochemical analysis was utilized to localize and characterizethe IGF - R1 immuno positive cells at the wound site of allgroups (experimental and control).Results : Histological findings of the present study have shown that reepithelialization, wound contraction were accelerated after topical application of curcumin and essential oil. The results ofimmunohistochemical examination of this study revealed that there was increased expression of IGF - 1R by epithelial and connective tissue cells of skin especially with the topical application of curcumin oil at wound site.Conclusion : - Essential oil is more effective in enhancement of wound healing regarding histological and immuonohistochemical assessment revealed higher mean values of positive expression for insulin growth factor1receptor(IGF - 1R) , (for both stromal and epidermal).
