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الاجهاد التاكسدي وفرط الدهون في داء السكري == Oxidative Stress And Hyperlipidemia In Diabetes Mellitus

اسم المؤلف: محمد عباس خليبص الناشي

اسم المشرف: ماجد كاظم حسين

الموضوع العام: علوم الكيمياء

السنة: 2008

الموضوع الدقيق: الكيمياء الحياتية السريرية

الدرجة: ماجستير

الجامعة: جامعة الكوفة - كلية التربية للبنات - قسم الكيمياء

اللغة: الانكليزية

مكان الجامعة: النجف

الصفحات الاولى: 📎 25T543 - p.pdf

المستخلص: The present study aims at investigating the relationship b etween oxidative stress and hyperlipideamia in diabetes mellitus. For this purpose,(120) diabetes patients were chosen (48 type1 patients and 72 type2 patients). This sample of (120) patients was compared with a group of (50) healthy subjects. The malondialdehyde (MDA) (one of the markers of oxidative stress), serum total cholesterol(S.TC),triglycerides (S.TG) high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL) and very low density lipoprotein triglycerides (VLDL) were all measured via the enzymatic methods. Results indicated a significant increase(p<0.05) in the levels of (MDA),(S.TC),(S.TG),(HDL),(LDL) and (VLDL) in diabetes patients of both types, as compared with healthy subjects. The same fact holds when comparing the two types of patients. A significant increase (p<0.05) was also observed in the levels of (MDA),(S.TC),(S.TG),(HDL),(LDL) and (VLDL) in male and female diabetes patients of type1 as compared with healthy subjects. As for type2 patients the increase in the same values was(p<0.01) as compared with healthy subjects. The comparison of male and female patients showed a significant increase(p<0.05) in the levels of (S.TC),and (VLDL) only in type1. It was also found that age is an influential factor in the criteria of serum lipids and (MDA) levels in patients of both types, except in case of(S.TG)and(VLDL) in type2 patients where age proved irrelevant. Moreover, results indicated that (BMI) has an impact on (MDA),(S.TC),(S.TG),(LDL) and (VLDL) levels. The duration of the disease in patients of both types also produced a significant increase(p=0.05) in (MDA) levels and serum lipids criteria. The complications suffered by the patients because of diabetes also produced a significant increase (p<0.05 - p<0.005) in (MDA) levels and serum lipids criteria as compared with those free of such complications for both types. No significant correlation was found between MDA level and levels of serum lipids in all patients and in both types except(VLDL) in type2. All these results prove the correlative relationship between oxidative stress and serum lipids criteria in diabetes mellitus.