دراسة عدد من المعايير الكيموحيوية والاجهاد التاكسدي لدى المرضى المصابين ببعض امراض القلب == The Study of Some of Biochemical Criteria And Oxidative Stress In Patients With Certain Heart Diseases
Author name:
منى احمـد لفتة النيسانـي
Supervisor name:
زيد محمد مبارك المهداوي | موسى جاسم محمد الحميش
General topic:
Biology
Specific topic:
Zoology
Degree:
Master
University:
Tikrit University - Faculty Of Education - Department Of Biology
Language:
Arabic
University location:
Salahaddin
First pages:
24T2835 - p.pdf
Abstract:
صممت الدراسة الحالية لمعرفة تاثير الاجهاد التاكسدي لدى المرضى المصابين ببعض امراض القلب عن طريق اجراء بعض الاختبارات والقياسات كالنسبة المئوية لحجم كريات الدم المرصوصة (PCV) وتركيز خضاب الدم (Hb)، وبعض الانزيمات مثل : تركيز انزيم ناقل امين الاسبارتيت (AST | The current study was designed to determine the effect of oxidative stress in patients with the certain heart diseases through some tests and measurements as the Packed Cells Volume Percentage (PCV) and hemoglobin concentration (Hb), and some enzymes as : the Concentration of Enzyme Aspartate Aminotransferase (AST), Creatine Phospho Kinase (CPK), Total Lactate Dehydrogenase (LDH), and Lactate Dehydrogenase For Heart Muscle, and some of antioxidants and oxidation factors as : Glutathione (GSH), and Malondialdehyde (MDA) respectively, and lipid profile that include : the Concentration of Total Cholesterol, Triglycerides (TG), High Density Lipoprotein of Cholesterol (HDL - C), Low Density Lipoprotein of Cholesterol (LDL - C), and Very Low Density Lipoprotein of Cholesterol (VLDL - C), and some other biochemical criteria as : the Concentration of Glucose, Total Protein, Albumin, Globulin, Urea, and Creatinine. It was chosen (95) blood sample back to the (80 patients and 15 healthy people), the samples were divided into four groups : The first group : included patients with Myocardial Infarction and they was (40) patients (males and females), age ranged between (35 - 89) years old.The second group : included patients with Angina Pectoris and they was (20) patients (males and females), age ranged between (32 - 85) years old.The third group : included patients with Heart Failure and they was (20) patients (males and females), age ranged between (39 - 89) years old.The control group : included (15) people (males and females), age ranged between (30 - 57) years old. The current study showed the following results : A. A significant decrease in the level (p <0.05) in : 1 - The Packed Cells Volume Percentage (PCV) and the concentration of Hemoglobin (Hb) in the heart failure group within the group of (males+females) and females gender.2 - Concentration of Glutathione (GSH) in the three pathological groups within the groups of males and females and (males+females) and age groups (60 years old and above).3 - Concentration of (HDL - C) in the three pathological groups for males and (males+females).4 - Concentration of Total protein in the myocardial infarction group for males and in the heart failure group for females and these two groups within the group of (males+females) and smokers.5 - Concentration of Albumin in the myocardial infarction and heart failure groups for males and (males+females).6 - Concentration of Globulin in the heart failure group for females and (males+females).B. A Significant increase in the level (p <0.05) in : 1 - Concentration of Enzyme Aspartate Aminotransferase (AST) in the angina pectoris group for males and the heart failure group for females and these two groups within the group of (males+females), males gender, diabetes and smokers.2 - Concentration of Enzyme Creatine Phospho Kinase (CPK) in patients with myocardial infarction for males and female and (males+females), males gender, age group (80 - 89 years old), people with high blood pressure, diabetes and smokers.3 - Concentration of Enzyme Total Lactate Dehydrogenase (LDH) and Lactate Dehydrogenase For Heart Muscle in the myocardial infarction group for males and females and (males+females), males gender, age group (50 - 59 years old), diabetes and smokers.4 - Concentration of Malondialdehyde (MDA) in the heart failure group for males and females and (males+females) and females gender.5 - Concentration of Total Cholesterol in a group of angina pectoris for males and females and (males+females).6 - Concentration of Triglycerides (TG) in the myocardial infarction group for females and (males+females), males gender, diabetes and smokers.7 - Concentration of (VLDL - C) in the myocardial infarction group for males and females and (males+females), males gender, diabetes and smokers.8 - Concentration of (LDL - C) in the angina pectoris and heart failure groups for males and females and (males+females).9 - Concentration of Glucose in the heart failure group for males and myocardial infarction group for females and these two groups within the group of (males+females), males gender, age groups (50 - 79 years old), diabetes and smokers.10 - Concentration of Urea in the myocardial infarction and heart failure groups for males and females and (males+females) and age groups (from 60 - 79 years old).11 - Concentration of Creatinine in a myocardial infarction group for males and females and (males+females) and age group (70 - 79 years old).
