مدى تاثير العلاج الاشعاعي التلطيفي للدماغ في البقاء على قيد الحياة للمرضى الذين يعانون من ورم منتشر في الدماغ من مختلف انواع السرطانات == Impact of whole cranium Radiotherapy on Survival in Patients With Brain Metastasis of Different Cancers
Author name:
زينب علاء مكي الربيعي
Supervisor name:
خضير جاسم صبيح الرواق
General topic:
Medicine
Specific topic:
Therapeutic Radiology
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1604 - p.pdf
Abstract:
Brain metastases are the most common intracranial brain tumor and a common complication of systemic cancer. The incidence ranges from 20% to 40% of all patients diagnosed with cancer ,The most common primary site is the lung followed by breast. Metastatic brain tumors outnumber primary brain tumors by a factor of 10 to 1 , The prognosis of brain metastases is poor and the impact on the patient’s quality of life is important as a result of the functional neurologic deficits associated. The mainstay of treatment for brain metastases has been corticosteroids and whole brain radiotherapy.Objective : the aim of the study to determined the impact of whole cranium irradiation (2000cGy) on median and mean survival of brain metastasis and to analyze prognostic factors affecting survival of patients receiving whole brain irradiation (WBI).Patients & Methods : This study retrospectively reviewed the records of 80 patients with BMs who were not eligible for surgical resection and who underwent WBRT in Baghdad oncology teaching hospital between 1stof July 2015 and 1st of January 2017. The patients enrolled in this study, About 47 Patients were diagnosed as primary breast cancer,20 patients as primary lung cancer and 13 patients from other site of body. All patients were treated with conventional external beam radiotherapy with atotal dose of 20 Gy in five fractions over 1 week for all patients.Results : Breast cancer represented the most common primary cancer type 47 patients (58.8%), followed by lung cancer 20 patients (25%) ,other types of primary represent 13 patients(16.3%), The median survival for the total population Who were receiving Whole cranium radiotherapy was 7 months and mean survival was 9.8 months,For breast cancer the median survival time was 8 months, for lung cancer patients was 6 months and for primary metastasis from other sites of body was 6 months, In general, the result is that patients with breast cancer had better survival than patients with other primary cancers. In regard of time to develop to brain metastasis ,median time for breast cancer, lung cancer and for other sites (22,5,12 months)respectively The breast cancer has the longest time before progress to brain metastasis, According to the stage of primary breast tumor, The highest frequency was seen among patients with T3A followed by T2B and T3B respectively, while the lowest frequency with T1B. Our study reported a strong correlation between the tumer stage and time to brain metastasis with significant P value = 0.033In regards of primary breast cancer metastasis ,The results showed that HER2 overexpressed were 19 patients (40.4%), Triple negative were 10 patients (21.3%) ,Luminal A - like were 9 patients (19.1%) and Luminal B - like were 9 patients (19.1%),. The highest frequency was seen among patients with HER2 overexpressed followed by triple negative.Our results showed a negative correlation between the molecular subtypes and time to develop of brain metastasis with P value = 0.482 which was statistically not significant
