تحضير وتشخيص وتقييم الفعالية البايولوجية لمعقدات جديدة مختلطة الليكاند مشتقة من مضادات حيوية مختارة == Synthesis, Characterization and Investigation the biological Activity for new mixed - ligand complexes derived from selected antibiotics
Author name:
احمد حسين اسماعيل
Supervisor name:
رحيم طاهر مهدي الساعدي | تغريد هاشم النور
General topic:
Chemistry
Specific topic:
Inorganic Chemistry
Degree:
Doctorate
University:
Mustansiriyah University - College Of Science
Language:
English
University location:
Baghdad
First pages:
25T1700 - p.pdf
Abstract:
The work in this thesis has been described as follows : First : synthesis and characterization of the three Schiff bases ligands (HL1,HL2 and L3) by condensation of Cephalexin mono hydrate, Ampicillin tri hydrate and Sulfamethoxazole antibiotics respectively with 2,4 - Dimethoxybenzaldehyde (as shown in the table below) containing (N,O,O) as donor atoms types [(NOO - for HL1 & HL2 ) and (N O)] of (L3).Symbol Chemical formula Schiff bases derived fromHL1C25H25N3O6 SCephalexin mono hydrate + 2,4 - Dimethoxybenzaldehyde HL2C25H27N3O6 SAmpicillin tri hydrate + 2,4 - Dimethoxybenzaldehyde L3C19H19N3O5 SSulfamethoxazole + 2,4 - DimethoxybenzaldehydeThe synthesized ligands (HL1, HL2, L3) were characterized by using (mass spectrometry), (1H NMR), (FT - IR) and (U.V - Vis) spectra as well as (C.H.N.S) elemental analysis and melting point. According to the results obtained from different technics in above, the molecular modeling of the proposed structures of ligands were drawing by using Cs Chem 3D Ultra program package (2006). As shown in figures below (three dimensional view of ligands with IUPAC names).IIOHOHN NO OHSNOO(HL1 )(6R,7R) - 7 - (2 - ((E) - 2,4 - dimethoxybenzylideneamino) - 2 - phenylacetamido) - 3 - methyl - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - ene - 2 - carboxylic acid.CH3NHHNSHCH3OOHOOO NO(HL2)(Z) - 6 - (2 - (2,4 - dimethoxybenzylideneamino) - 2 - phenylacetamido) - 3,3 - dimethyl - 7 - oxo - 4 - thia - 1 - azabicyclo[3.2.0]heptane - 2 - carboxylic acid .OOSOONHONN(L3)(E) - 4 - (2,4 - dimethoxybenzylideneamino) - N - (5 - methyl isoxazol - 3 - yl) benzenesulfonamide.IIISecond : Synthesis of Mixed - Ligand metal complexes1 - Synthesis Mixed - Ligand [(L1 - tbph, L2 - tbph) & (L3 - Asn)] Metal complexes in which Schiff bases ligands (HL1, HL2) & (L3) are used as primary ligands with tributylphosphine (tbph) & L - Asparagine (AsnH), respectively as secondary ligands with M (II) ions : where M(II) = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II).2 - Synthesis Mixed - Ligand (antibiotics) [Ceph - tbph, Amp - tbph) & (SMX - Asn, SMX - Leu)] in which Cephalexin, Ampicillins and Sulphamethoxazole are used as primary ligands with (tbph) & (AsnH, LeuH) respectively as secondary ligands with M(II) complexes (as shown in the table below).where M(II) = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II).Products were found to be solid complexes, which have been characterized through the following techniques : Molar conductivity, magnetic susceptibility measurement and spectroscopic methods i.e., [FT - IR, UV - Vis and AA] .According to the results obtained from the different techniques in above leads to suggestion of the suitable geometry for the prepared complexes.3 - The free ligands and their metal complexes were screened for their antibacterial activities against different species of pathogenic bacteria : E - coli( - ), Staphyloccus aureus (+), Acinetobacter baumannii ( - ) and Pseudomonas ( - ). In order to assess their antimicrobial and their bio potency has been discussed.4 - Study the effect of the ligand and some prepared mixed - ligand metal complexes toward activity of two type of enzymes (GOT and GPT).
