تقييم بعض الدلائل الحيوية وصورة الدهون وعلاقتها مع مرضى السكري من النوع الثاني == Assessment of Some Biomarkers And Lipid Profile In Relation With Diabetic Patients Type 2
Author name:
عذراء باقر حسن الشيباوي
Supervisor name:
ارشد نوري غني الدجيلي
General topic:
Biology
Specific topic:
Zoology - Physiology
Degree:
Doctorate
University:
University of Kufa - College Of Science - Department Of Biology
Language:
English
University location:
Najaf
First pages:
24T2705 - p.pdf
Abstract:
لازال البحث مستمرعن ايجاد متغيرات جديدة قد تساعد في تشخيص ومتابعة مرض السكر وهو من المجالات المهمة في ميادين البحث العلمي حيث ركزت بعض الدراسات على حالة الانسولين بينمراكزت بحوث اخرى على صورة الدهون والشدة التاكسدية كاسباب للسكري. اجريت هذه الدراسة لمرض | The search of a new parameters for monitoring and even prediction of diabetes mellitus (DM) are still an important issue in many research fields. Some studies focused on the role of insulin status, while others concentrated on lipid disturbances or even oxidative stress disorders in the diabetes. This study was conducted on randomly selected 68 type 2 diabetic patients (27 Males and 41 Females) attending the diabetes mellitus center in Al - Sadder Teaching Hospital in Al - Najaf province, Iraq and a group of 20 apparently healthy subjects (10 Males and 10 Females) were included as a control group. The study was carried out from February 2013 to July 2013. The age of patients and control groups were range of 35 - 65years. The concentration of fasting blood glucose, cholesterol, triglyceride, LDL, VLDL, HDL, Apelin, Omentin, Vaspin, Visfatin and BMI were estimated in patients and control groups. The results show significant increase (P?0.05) in fasting blood glucose, cholesterol, triglyceride, LDL, VLDL, Apelin, Vaspin and Visfatin levels in patients compared with control groups, also the results show significant decrease (P?0.05) in HDL and Omentin level in patients compared with control groups. The results revealed that all biomarkers (Apelin, Omentin, Vaspin and Visfatin) not significant difference (P>0.05) in patients at different ages. The results also revealed that biomarkers (Apelin, Vaspin and Visfatin) levels increase significantly (P?0.05) in males than females in both patients and control groups, while the result of omentin level reveal no significant difference (P>0.05) between males and females in both patients and control groups. The results also revealed that significant increase (P?0.05) in BMI in patients compared with control groups. The results also show that biomarkers (Apelin, Vaspin and Visfatin) concentration increase significantly (P?0.05) with increasing BMI in males than females compared with control groups, while the result of omentin concentration show no significant difference (P>0.05) in patients and control groups and show lower significantly increase (P?0.05) in females than males compared with control groups. The results have been shown significant positive correlation (P?0.05) between biomarkers (Apelin, Vaspin and Visfatin) and FBG, cholesterol, triglyceride, LDL and VLDL in patients (males and females), while the results have been shown significant negative correlation (P?0.05) between biomarkers (Apelin, Vaspin and Visfatin) and HDL in patients (males and females). The results also have been shown significant negative correlation (P?0.05) between omentin and FBG, cholesterol, triglycerides, LDL and VLDL in patients (males and females), while the results have been shown significant positive correlation (P?0.05) between omentin and HDL in patients (males and females). The results also have been shown no significant correlation (P>0.05) between Vaspin and FBG in patients (males and females). The present study concluded that Apelin, Omentin, Vaspin and Visfatin levels maybe that could be adopted as markers for detection and diagnosis of diabetic patients type 2.
