دور البروتينات المولدة للاوعية الدموية (Soluble fms - like tyrosine kinase - 1 & placental Growth Factor) ومستوى مؤشر الاجهاد التاكسدي (Glutathione peroxidase) في حالات الاجهاض المهدد == The Role Of (Soluble Fms - Like Tyrosine Kinase - 1 & Placental Growth Factor) And Oxidative Stress Marker (Glutathione Peroxidase) In Threatened Miscarriage
Author name:
سرى عبد الكريم عصمت
Supervisor name:
ثابت نعمان وحيد العزاوي | هند عبد الخالق ناصر
General topic:
Medicine
Specific topic:
Clinical Biochemistry
Degree:
Master
University:
Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language:
English
University location:
Baghdad
First pages:
19T1167 - p.pdf
Abstract:
المقدمة : يعرف الاسقاط المهدد بانه حالة يمكن ان تصيب معظم النساء الحوامل في بداية الاشهر الثلاث الاولى من الحمل ,يتميز بحدوث نزيف مهبلي مصاحب بالام في البطن والظهر ويمكن ان ينتهي اما بحدوث اجهاض فعلي وموت الجنين او اكمال اشهر الحمل والانتهاء بالولادة.الهدف | Threatened abortion can defined as failure of pregnancy and vaginal bleeding and this occur before twentieth weeks of pregnancy. Aim of study : To evaluate association between maternal serum levels of angiogenic growth factors (sFlt - 1 & PlGF) with threatened abortion by compare it with control healthy level, to evaluate association between maternal serum level of oxidative stress marker (Glutathione peroxidase) with threatened abortion by compare it with control healthy level. To investigate if maternal serum levels of these parameters can be used as predictive markers for outcome of threatened abortion. Subjects & Method : Eighty six women were included in this study with age range from (20 - 35) years, all women attended to Obstetrics and Gynecology department / Alyarmook hospital during period from December 2015 to March 2016.Subjects were divided into three groups(1)Non pregnant women (in luteal phase) : 16 women serve as control group ( 2) Normal pregnant women with gestational age between (6 - 12) weeks : 20 women serve as patient study group(3) Threatened abortion women with gestational age between (6 - 12) weeks with vaginal bleeding : 50 women serve as patient study group. All threatened abortion women had been followed up for 6 months to determine whether they complete their pregnancies with live birth or subsequent miscarriage. Women with or without history of previous abortion, cigarette smoking were included and excluded women with age below 20 years and above 35 years or with diseases like (Hypertension, Diabetes mellitus, Hyperthyroidism) and women in follicle phase. All serum samples were analyzed for soluble fms - like tyrosine kinase - 1 (sFlt - 1), placental growth factor (PlGF) and Glutathione peroxidase by using (ELISA) technique.Results : There was significant lowering in mean value level of sFlt - 1 in threatened abortion women (8.5 ± 4.4 ng/ml) than normal pregnant women (13.8 ± 3.2 ng/ml)and non - pregnant women (15.3 ± 3.2 ng/ml), P value
