تحضير بعض الفورمازنات والثايازوليدينونات الجديدة ودراسة فعالية بعض المركبات المحضرة في خفض سكر الدم
Author name:
هبة محمد داغر راشد
Supervisor name:
حيدر عباس مهدي | كريم سالم عباس
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Thi-Qar - College Of Science - Chemistry Department
Language:
English
University location:
Dhi Qar
First pages:
25T1878 - p.pdf
Abstract:
The thesis consists of three chapters. The first chapter is concerned with the introduction described the chemistry of Schiff bases , formazans and thiazolidinones compounds including importance , applications , synthesis and literature reviews.The second chapter describes the chemicals and solvents which were used in the synthesis of the new Schiff bases, formazans and thiazolidinones derivatives, physical measurements , synthesis methods of compounds and evaluation of anti - hyperglycemic activity. The formazans compounds[4a - 4h] were prepared by reacting diazonium salts amines[3a - 3c] with the appropriate Schiff bases[2a - 2h].Schiff bases themselves are synthesized by the condensation of different primary amines with various aromaticaldehydes. The thiazolidinones derivatives[5c,5e,5i,5j,5k] are synthesized by condensing thioglycolic acid with various Schiff bases[2a - 2h]. All the structures prepared [2a - 2k] , [4a - 4h] and [2c, 2e ,2i ,2j , 2k] were shown in scheme(1), and characterized on the basis of the spectral data : IR, Mass, 1H and 13C NMR. The third chapter deals with , the results and discussion. The IR spectra show an important absorption band at (1558 - 1689)cm - 1 attributed to azomethine (C=N) for Schiff bases, the IR spectra showed important absorption band at (1681 - 1597 )cm - 1 attributed to azomethine (C=N) and (1465 - 1558) cm - 1 to ( - N=N - ) for formazans derivatives. Also, the IR spectra show an important absorption band at (1689 - 1658)cm - 1 attributed to the thiazolidinones ring . The 1H - NMR spectra of formazans show aromatic protons at the range (7.07 - 8.49 )ppm and pyridyl protons as downfield signal at (8.22 - 9.15 ) hydrazide signal at 11 ppm. The 1H - NMR of thiazolidinones exhibit new signals attributed to - CH2 and - CH of thiazolidnones ring at δ (4.52 - 4.71) and (5.70 - 5.81 ) ppm, respectively .13C - NMR spectra of formazans exhibit that the a signal at 156 - 168 ppm (amide carbonyl) , thiazolidinones show a signal at (207.35 - 208 .60) ppm attributed to the C=O ring thiazolidinones.The mass spectra of the formazans compounds [4d ,4e, 4g , 4h] show a molecular ion peak. M+(354 .401 . 516. 498) m/z corresponding to the target compounds. Also, mass spectra of thiazolidinones compounds [5e, 5i] show molecular ion peak. M+ (356 , 369 ) m/z corresponding to the target compounds .This study is also concerned with anti - hyperglycemic activity ,and male mice (Mus musculus Balb/c ) weighing (25 - 35)gm were used for the study of the effects of formazan compound [4e] and thiazolidinone compound [5e] on the blood glucose levels of the animals.Animals are divided into seven different groups, Group (A) : negative control (normal) that is only treated with distilled water (D.W). Group (B) : positive control that is treated with alloxan (125mg/kg) B.W. only to induce diabetes. Group (C) : that is only treated with (DMSO) only. Group (D) : alloxan - induced diabetes mice that are treated with (75 mg/kg) of formazan derivative [4e]. Group (E) : alloxan - induced diabetes mice that are treated with (150 mg/kg) of formazan derivative [4e]. Group (F) : injected alloxan and thiazolidinone [5e] (75 mg/kg). Group (G) : injected alloxan and compound thiazolidinone [5e] (150 mg/kg) .The mice were treated for two weeks and used Colorimetric to Determination of serum Glucose Level by spectrophotometer. The results how that the determination of serum glucose concentration is in males mice groups (A , B , C , D, E , F and G ).A significant decrease can be observed among ( D, E, F and G) groups as compared with group (A) after treatment (2 week) with (75 mg /kg) and (150 mg /kg ) respectively of formazans [4e] and also treatment with(75 mg /kg) and (150 mg /kg ) from thiazolidinone [5e] . while groups (A , C ) do
