تحضير ودراسة الفعالية الحيوية لمعقدات الامينية ثنائية السن مع ايونات ا لبلاتين (III) والروديوم (II) والبلاديوم == Synthesis , Characterization and Biological Activity Study of Some New Compound Containing Amine and Azomethine Group and Their Complexation Reaction with Platinum(II) , Palladium (II) and Rhodium(III)
Author name:
احمد ليث عبد الحليم
Supervisor name:
عادل علي عبد الحسن | بشرى كامل جدوع
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University Of Basrah - College Of Science - Chemistry Department
Language:
Arabic
University location:
Basrah
First pages:
25T1574 - p.pdf
Abstract:
This study included the preparation and the diagnosis and study the biological activity of some new organic compounds containing amine and azomethine groups and complexes ions with platinum(II) and palladium (II) and rhodium (III) ions.This thesis is divided into four chapters. In the first chapter, a general introduction for platinum metals group and of their complexes including : amine and Schiff base ligands have been literately reviewed. The concerned complexes have related to drugs potentially are anticancer active, therefore, this chapter summarized the important roles between the structure and activity for potentially active anticancer drugs which containing platinum metal complexes .The second chapter of this thesis shows the preparative methods of two types of ligands. The first type ligands concerned preparation method of two newly bidentate amine ligands namely : N - (3 - phenylpropyl)ethane - 1,2 - diamine (1) and N,N' - bis(3 - phenylpropyl) ethane - 1,2 - diamine (2) by reaction of ethylene diamine with 3 - phenypropyl bromide in 1 : 1 and 1 : 2 mole ratio, respectively. The second type ligands concerned preparative methods of six newly Schiff base ligands by reacting of o - phenylenediamine with 2 - furyldehyde, ferrocenecarboxaldehyde and acetylferrocene in the mole ratio 1 : 1 and 1 : 2respectively namely : N - 2 - furylidinebenzene - 1,2 - diamine (3)N,N' - bis(furylidine)benzene - 1,2 - diamine(4)N - ferrocenidenebenzene - 1,2 - diamine (5)N,N' - bis(ferrocenidene)benzene - 1,2 - diamine (6) N - 1 - ferrocenylethylidenebenzene - 1,2 - diamin (7) N,N' - bis(1 - ferrocenylethylidene)benzene - 1,2 - diamine (8) o , this chapter describes the synthesis of a new twenty four complexes ofPt(II), Pd(II) and Rh(III) ions with ligands (1 - 8) . The third chapter includes the results and discussion. All the prepared compounds 1 - 32 were characterized by elemental analysis CHN, Conductivity measurements , 1H - NMR ,FT - IR and UV - Visible spectroscopic techniques. All the prepared compounds 1 - 32 are in good agreement with the suggested structure. These data confirmed that the prepared ligands 1 - 8 coordinate with Pt(II),Pd(II) and Rh(III) ions by nitrogen atoms of amino and azomethine groups as a bidentate ligands. The molar conductivity study indicate that platinum(II) and palladium (II) complexes are neutral and behave as non - electrolytes in DMSO solvent at room temperature while rhodium (III) complexes behaves as 1 : 1 electrolytes in the same conditions.Antibacterial activity of all the prepared compounds 1 - 32 beside their interaction with human DNA are shown in the fourth chapter of this thesis. The antibacterial activity of compounds 1 - 32 against two types of bacterial : the first negative towards Gram stain (i.e. Escherichia coli) and against positive towards Gram stain (i.e. Staphylococcus aureus) were tested. These data proved that only compounds 1, 2, 4, 5, 6, 7, 20, 29 and 32 have antibacterial activity for growth inhibition of Staphylococcus aureus whereas only 1, 2, 4, 21 and 29 have antibacterial activity for Escherichia coli. On the other hand, DNA interaction study of complexes 9 - 32 with human DNA showed that all these complexes are binding with DNA which is enhances the probability of usingthese complexes as drug alternatives.
