تغيرات الرسم الكهربائي للدماغ عند الحوامل في مرحلة ما قبل التشنج الحملي وعلاقتها ببعض المؤشرات الحيوية الالتهابية == Electroencephalographic Changes In Preeclamptic Females And Their Relation With Some Inflammatory Biomarkers
Author name:
مهند يحيى ادريس المحنه
Supervisor name:
احسان محمد عبود عجينة
General topic:
Medicine
Specific topic:
Physiology
Degree:
Doctorate
University:
University of Kufa - Faculty Of Medicine - Department Of Physiology And Medical Physics
Language:
English
University location:
Najaf
First pages:
19T1109 - p.pdf
Abstract:
يسجل الرسم الكهربائي للدماغ الفعالية الكهربائية الذاتية المتولدة في قشرة الدماغ. اشارة الرسم الكهربائي للدماغ هي قياس للتيارات المتحركة في قشرة الدماغ. عندما تحفز خلايا الدماغ (العصيبات), يتم توليد التيار الارتباطي في التشجرات العصبية للخلايا. يولد هذا ال | Electroencephalography (EEG) records the spontaneous electrical activity generated in the cerebral cortex. When brain cells (neurons) are active, synaptic currents are produced within their dendrites and this current generates an electrical field over the scalp. The EEG waves measure this current that flow during synaptic excitations of pyramidal neurons' dendrites. Preeclampsia is a disease of pregnancy characterized by a blood pressure of 140/90 mmHg or more on two separate occasions after the 20th gestational week in a previously normotensive woman. This is accompanied by significant proteinuria (>300 mg in 24 hours) and is associated with endothelial cell damage. The markers of endothelial activation or inflammation have been blamed to play an active role in preeclampsia (Sibai et al., 2005). This study included 97 pregnant with a confirmed diagnosis of preeclampsia as a patient group with a gestational age ranging between 20 - 38 weeks. They are divided into three subgroups according to their gestational age (20 - 26 wk, 27 - 32 wk and 33 - 38 wk) and the mean of their age was 29.34±4.82, 30.14±5.33 and 32.54±6.22 years respectively. In addition, 72 women with normal pregnancy have been included as control group. These were also subdivided into three subgroups just like that of the patients and their age matches them too. Participants belong to both patient and control groups had underwent same procedure, examinations and tests like EEG and serological tests for Intracellular Adhesion Molecule 1 (ICAM I), interleukin - 6 (IL6) and C - reactive protein (CRP), in parallel. Results showed that there were statistically significant increased levels (P < 0.05) of ICAMI, IL - 6 and CRP values between patient and control groups and between the patient with mild and those with severe preeclampsia in all tested gestational age subgroups. This supports the hypothesis stating a role of cytokines and inflammatory biomarkers in the mechanism underlying preeclampsia. Moreover, and at all gestational age subgroups, the ICAMI, CRP and IL - 6 values were higher in patients with severe disease when compared with those having milkd disease. This strengthens more the relation of these biomarkers with the progression of preeclampsia. There were abnormal EEG changes in about 52 % of the patients with preeclampsia and these changes were reported in all gestational age subgroups and were in the form of spikes, polyspikes, slow sharp waves. This shows that preeclamptic females are prone to some excessive brain activities that may put them in danger of abnormal brain function. Furthermore, these EEG abnormalities were related to the severity of the preeclampsia as they were recorded in severe cases more and at all gestational age subgroups. Also there were statistically significant elevation regarding ICAMI (at the second and third gestational age subgroups), IL - 6 values (at the second gestational age subgroup) and CRP (at all gestational age subgroups) among patients with and without abnormal EEG changes. This suggests a strong relation between these inflammatory biomarkers with the occurrence of abnormal EEG changes in preeclamptic females. In conclusion, an inflammatory process is blamed to be the underlying mechanism of preeclampsia as proved by the elevated levels biomarkers in these patients. Both the abnormally elevated biomarkers and the abnormal EEG changes occur in preeclamptic patient in different gestational ages above 20 weeks and occur in different disease severity.
