تحضير وتشخيص ودراسة الفعالية البايولوجية المحتمله لبعض مشتقات 5,4 - ثنائي فنيل ايميدازول == Synthesis, Characterization And Study of The Potential Biological Activity of Some - 4,5 - Di Phenyl Imidazole Derivatives
Author name:
منار غياث عبد المطلب الموسوي
Supervisor name:
حسن ثامر غانم
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Kufa - College Of Science For Girls - Chemistry Department
Language:
Arabic
University location:
Najaf
First pages:
25T1463 - p.pdf
Abstract:
برزت اهمية مركبات الثاياديازول لما لها من فعالية بايولوجية وتطبيقات دوائية، ونظرا لاهمية الازو صناعيا وبايولوجيا لذا تم تحضير مشتقات ازو للثايادايازولات باستخدام المشتق 2 - amino - 5 - thiol - 1,3,4 - thiadiazole كاساس في هذا البحث وكما ياتي : 1 - تحضير ا | Recently, the signifificance of thiadiazole compounds appeared form their biological activity and medical applications therefore.Azo thiadiazole derivatives were prepared by using 2 - amino - 5 - thiol - 1,3,4 - thiadiazole as starting material in this research.1. Preparation of (A1) 2 - amino - 5 - thiol - 1,3,4 - thiadiazole through ring cyclization thiosemicarbazide in the presence of anhydrous sodium carbonate and CS2.[A1]2. Preparation of diazonium salt (A2) by reaction of compounds (A1) with sodium nitrate and hydrochioric acid at low temperature(0 - 50C) with stirring. [A2]3. Preparation of new azo compounds[A3 - A15] by the reaction diazonium salt [A2] with different aromatic compounds. [A3 - A15]4. Schiff bases [A16 - A23] have been prepared from the reaations of azo compounds [A3 - A5] with different aromatic aldehydes.[A16, A17, A18, A19, A20, A21, A22, A23]5. Preparation of new thio ester derivatives[A24, A25, A27] by reaction of azo compounds [A6, A7, A8] with acetyl chloride in the presence of pyridine. [A24, A25, A27] 6. Preparation of new thio ester derivatives [A26, A28] by reaction of azo compounds [A8, A9] with 2 - chloro benzoyl chloride in the presence of pyridine. [A26, A28]7. Preparation of new thio ether derivatives [A29, A30] by alkylation of azo compounds [A11] with bromo butane and bromo pentane in the presence of NaOH. [A29, A30]8.Melting boints of all prepared compounds have been measured and some of physical properties were studied lnddition, the structure eluciclation of a bove compound was carried out by using some spectroscopic methods (F.T.I.R and UV).
